2-(Methylamino)-1,1,3-triphenylpropan-1-ol | 1140920-13-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(Methylamino)-1,1,3-triphenylpropan-1-ol
• CAS: 1140920-13-3
• 化学式: C₂₂H₂₃NO
• 分子量: 317.431
• InChiKey: RILHNOHVAGZWAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 2-(Methylamino)-1,1,3-triphenylpropan-1-ol 在 硫酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Novel organosoluble filiform zirconium phosphonates with a layered mesoporous backbone

  摘要：

  通过功能化磷酸与ZrOCl2·8H2O反应制备了一种新型有机可溶性丝状膦酸锆，其具有羟基和氨基功能化的层状介孔主链。这些丝状膦酸锆在某些有机溶剂（如甲苯、氯仿、四氢呋喃和乙酸乙酯）中具有良好的溶解度（0.21–0.71 g mL−1），与其他一些溶剂（己烷、环己烷、石油醚和乙醇）不混溶，并且可以通过沉淀从有机溶剂中以高收率（95-100%）回收。

  DOI：

  10.1039/b816542d

文献信息

• Pyrrolidine derivatives and method of synthesizing these
  申请人：——

  公开号：US20040236118A1

  公开（公告）日：2004-11-25

  The object of the invention is to provide a process for efficient, inexpensive and stereoselective production of (2S,4S)-2-[[(3R)-pyrrolidin-3-yl-(R)-hydroxylmethyl]pyrrolidin-4-thiol dihydrochloride useful as an intermediate in production of novel carbapenem, and the intermediate is produced via a novel crystallizable intermediate (2S,4R)—N-t-butoxycarbonyl-2-[[(3R)—N-t-butoxycarbonyl pyrrolidin-3-yl-(R)-hydroxylmethyl]-4-hydroxypyrrolidine from a (2S,4R)-4-alkylsilyloxy-N-t-butoxycarbonylpyridine-2-carbaldehyde derivative by aldol reaction using an asymmetric assistant such as amino-alcohol.

  本发明的目的是提供一种高效、廉价和立体选择性生产(2S,4S)-2-[[(3R)-吡咯啉-3-基-(R)-羟甲基]吡咯啉-4-硫醇二盐酸盐的方法，该方法是通过使用一种新的可结晶中间体(2S,4R)-N-叔丁氧羰基-2-[[(3R)-N-叔丁氧羰基吡咯啉-3-基-(R)-羟甲基]-4-羟基吡咯烷通过使用氨基醇等不对称助剂的醛缩反应从(2S,4R)-4-烷基硅氧基-N-叔丁氧羰基吡啶-2-甲醛衍生物中制备的，该中间体可用作新型头孢菌素的中间体。
• Novel optically active imidazolidin-2-one derivatives and their production
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0044158A1

  公开（公告）日：1982-01-20

  A novel optically active cis-4,5-disubstituted imidazoli- din-2-one derivative of the formula; wherein R1 is a C,-C4 alkyl group or benzyl and R2 is a chiral aralkyl group optionally containing at least one C1-C4 alkyl, C1-C4 alkoxy or hydroxyl group is produced asymmetrically by the reaction of 1,3-dibenzyl-cis-4,5-dicarboxy- imidazolidin-2-one or its anhydride with an optically active secondary amine of the formula: wherein R1 and R2 are each as defined above and is transformed into the lactone of 1,3-dibenzyl-cis-4-carboxy-5-hydroxymethyl-imidazolidin-2-one, which is a key intermediate in the synthesis of d-biotin.

  一种新型光学活性顺式-4,5-二取代咪唑-2-酮衍生物，其式如下 其中 R1 为 C,-C4烷基或苄基，R2 为手性烷基，可选含有至少一个 C1-C4 烷基、C1-C4 烷氧基或羟基，由 1,3-二苄基-顺式-4,5-二羧基咪唑啉-2-酮或其酐与式中光学活性仲胺反应不对称生成： 其中 R1 和 R2 分别如上文所定义，并转化为 1,3-二苄基-顺式-4-羧基-5-羟甲基-咪唑烷-2-酮的内酯，它是合成 d-生物素的关键中间体。
• Optically active amino alcohols and their production
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0075868A2

  公开（公告）日：1983-04-06

  An optically active amino alcohol of the formula: wherein R' is a lower alkyl group, a benzyl group or a phenyl group, R2 is a benzyl group, a phenyl group or a phenyl group substituted with at least one of lower alkyl and lower alkoxy, R3 and R4 are each a hydrogen atom, a lower alkyl group or a phenyl group and the carbon atom accompanied by an asterisk (*) indicates an asymmetric carbon atom, which is useful as a chiral reagent for asymmtric synthesis of intermediates in the production of biotin.

  一种光学活性氨基醇，其式如下：其中 R' 为低级烷基、苄基或苯基，R2 为苄基、苯基或被低级烷基和低级烷氧基中至少一种取代的苯基，R3 和 R4 各为氢原子、低级烷基或苯基，星号（*）表示不对称碳原子，可用作手性试剂，用于生物素生产中间体的异构合成。
• PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE
  申请人：Eizai Co., Ltd.

  公开号：EP1413574A1

  公开（公告）日：2004-04-28

  The object of the invention is to provide a process for efficient, inexpensive and stereoselective production of (2S,4S)-2-[[(3R)-pyrrolidin-3-yl-(R)-hydroxy] methyl] pyrrolidin-4-thiol dihydrochloride useful as an intermediate in production of novel carbapenem, and the intermediate is produced via a novel crystallizable intermediate (2S,4R)-N-t-butoxycarbonyl-2-[[(3R)-N-t-butoxycarbonyl pyrrolidin-3-yl-(R)-hydroxy]methyl]-4-hydroxypyrrolidine from a (2S,4R)-4-alkylsilyloxy-N-t-butoxycarbonylpyridine-2-carbal dehyde derivative by aldol reaction using an asymmetric assistant such as amino-alcohol.

  本发明的目的是提供一种高效、廉价和立体选择性生产(2S,4S)-2-[[(3R)-吡咯烷-3-基-(R)-羟基]甲基]吡咯烷-4-硫醇二盐酸盐的工艺，该工艺可作为生产新型碳青霉烯的中间体、该中间体通过新型可结晶中间体(2S,4R)-N-叔丁氧羰基-2-[[(3R)-N-叔丁氧羰基吡咯烷-3-基-(R)-羟基]甲基]-4-羟基吡咯烷由(2S,4R)-4-烷基硅氧基-N-叔丁氧羰基吡啶-2-甲醛衍生物通过醛醇反应使用不对称助剂（如氨基醇）制得。
• US4403096A
  申请人：——

  公开号：US4403096A

  公开（公告）日：1983-09-06