1-chloro-3-(3,3,4,4,5,5,6,6,6-nonafluorohexylamino)propan-2-ol | 139978-09-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 1-chloro-3-(3,3,4,4,5,5,6,6,6-nonafluorohexylamino)propan-2-ol
• CAS: 139978-09-9
• 化学式: C₉H₁₁ClF₉NO
• 分子量: 355.631
• InChiKey: AKDNFLMXXHCCSJ-UHFFFAOYSA-N

物化性质

• 沸点：
  267.6±40.0 °C(Predicted)
• 密度：
  1.455±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.03
• 重原子数：
  21.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.26
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-chloro-3-(3,3,4,4,5,5,6,6,6-nonafluorohexylamino)propan-2-ol 在 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 反应 36.0h， 生成 1-(diethylamino)-3-(3,3,4,4,5,5,6,6,6-nonafluorohexylamino)propan-2-ol
  参考文献：
  名称：

  Synthèse de 3-[2F-alkyléthylamino]-1,2-époxypropanes et obtention de nouveaux tensioactifs mono ou bicaténaires à tête β-hydroxylée

  摘要：

  In this paper we report the synthesis of new intermediates of the type 3-[2-F-alkyl-ethylamino]-1,2-epoxypropanes which lead simply and with good yields to a large range of fluorinated monotailed, bitailed and hydrogenated/fluorinated bitailed surfactants having a secondary amino group and at least one hydroxy group. Evaluation of their surface properties has allowed the contribution of each hydrophobic tail contained in the hydrogenated and fluorinated bitailed molecules to be demonstrated.

  DOI：

  10.1016/s0022-1139(00)81248-8
• 作为产物：
  描述：

  3,3,4,4,5,5,6,6,6-nonafluorohexyl-1-amine 、 环氧氯丙烷 以 甲醇 为溶剂， 反应 24.0h， 以72%的产率得到1-chloro-3-(3,3,4,4,5,5,6,6,6-nonafluorohexylamino)propan-2-ol
  参考文献：
  名称：

  Synthèse de 3-[2F-alkyléthylamino]-1,2-époxypropanes et obtention de nouveaux tensioactifs mono ou bicaténaires à tête β-hydroxylée

  摘要：

  In this paper we report the synthesis of new intermediates of the type 3-[2-F-alkyl-ethylamino]-1,2-epoxypropanes which lead simply and with good yields to a large range of fluorinated monotailed, bitailed and hydrogenated/fluorinated bitailed surfactants having a secondary amino group and at least one hydroxy group. Evaluation of their surface properties has allowed the contribution of each hydrophobic tail contained in the hydrogenated and fluorinated bitailed molecules to be demonstrated.

  DOI：

  10.1016/s0022-1139(00)81248-8

文献信息

• Synthèse de 3-[2F-alkyléthylamino]-1,2-époxypropanes et obtention de nouveaux tensioactifs mono ou bicaténaires à tête β-hydroxylée
  作者：P.S. Abenin、F. Szönyi、A. Cambon

  DOI：10.1016/s0022-1139(00)81248-8

  日期：1991.11

  In this paper we report the synthesis of new intermediates of the type 3-[2-F-alkyl-ethylamino]-1,2-epoxypropanes which lead simply and with good yields to a large range of fluorinated monotailed, bitailed and hydrogenated/fluorinated bitailed surfactants having a secondary amino group and at least one hydroxy group. Evaluation of their surface properties has allowed the contribution of each hydrophobic tail contained in the hydrogenated and fluorinated bitailed molecules to be demonstrated.