Ethyl 8-(4-bromobenzoyl)-1-ethyl-2,3,5-trimethyl-5-phenylfuro[3,2-e][1,4]thiazepine-7-carboxylate 、
2-(三甲基硅)苯基三氟甲烷磺酸盐 在
cesium fluoride 作用下,
以
乙腈 为溶剂,
反应 1.5h,
以92%的产率得到ethyl 6-(4-bromobenzoyl)-5-ethyl-1,3,4-trimethyl-1-phenyl-1H-7,11b-epoxynaphtho[2,1-e][1,4]thiazepine-7(5H)-carboxylate