(2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)-(2-(thiophen-2-yl)ethyl)amine | 1187843-51-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)-(2-(thiophen-2-yl)ethyl)amine
• 英文别名: 2-phenyl-4-thiophen-2-yl-N-(2-thiophen-2-ylethyl)-1,3-thiazol-5-amine
• CAS: 1187843-51-1
• 化学式: C₁₉H₁₆N₂S₃
• 分子量: 368.547
• InChiKey: YFHLZROMFBCAJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)-(2-(thiophen-2-yl)ethyl)amine 、 异戊酰氯 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 3-methyl-N-(2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)-N-(2-(thiophen-2-yl)ethyl)butanamide
  参考文献：
  名称：

  Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives

  摘要：

  A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol its a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia its it convenient Source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into it variety of 5-aminoazole compounds through postcondensation modifications. Free or N-substituted 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology. The scope of the synthetic route developed and application of the different products are discussed.

  DOI：

  10.1021/jo9014529
• 作为产物：
  描述：

  N-[thiophen-2-yl-(2-(thiophen-2-yl)ethylcarbamoyl)methyl]benzamide 在 劳森试剂 作用下， 以 间二甲苯 为溶剂， 反应 0.33h， 以160 mg的产率得到(2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)-(2-(thiophen-2-yl)ethyl)amine
  参考文献：
  名称：

  Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives

  摘要：

  A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol its a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia its it convenient Source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into it variety of 5-aminoazole compounds through postcondensation modifications. Free or N-substituted 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology. The scope of the synthetic route developed and application of the different products are discussed.

  DOI：

  10.1021/jo9014529