ethyl-4-bromo-3-hydroxy-5-butyloxy-benzoate | 350035-54-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl-4-bromo-3-hydroxy-5-butyloxy-benzoate
• 英文别名: Ethyl 4-bromo-3-butoxy-5-hydroxybenzoate
• CAS: 350035-54-0
• 化学式: C₁₃H₁₇BrO₄
• 分子量: 317.18
• InChiKey: GGYGUNZUEJVFMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl-4-bromo-3-hydroxy-5-butyloxy-benzoate 在 四(三苯基膦)钯 potassium phosphate 、 锂硼氢 、 18-冠醚-6 、 四溴化碳 、 四丁基氟化铵 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 丙酮 为溶剂， 反应 110.0h， 生成 4-Bromomethyl-6-butoxy-3',5'-bis-(3-butoxy-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-biphenyl
  参考文献：
  名称：

  Toward Globular Macromolecules with Functionalized Interiors:  Design and Synthesis of Dendrons with an Interesting Twist

  摘要：

  [GRAPHCIS]Design and synthesis of a novel class of monodendrons, in which the functional units can potentially be directed toward the concave interiors of dendrimers, are described. The key feature of the design is the placement of the amphiphilic and the AB(2) functional groups in orthogonal planes.

  DOI：

  10.1021/ol016064b
• 作为产物：
  描述：

  4-溴-3,5-二羟基苯甲酸 在 18-冠醚-6 、 硫酸 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 12.0h， 生成 ethyl-4-bromo-3-hydroxy-5-butyloxy-benzoate
  参考文献：
  名称：

  Toward Globular Macromolecules with Functionalized Interiors:  Design and Synthesis of Dendrons with an Interesting Twist

  摘要：

  [GRAPHCIS]Design and synthesis of a novel class of monodendrons, in which the functional units can potentially be directed toward the concave interiors of dendrimers, are described. The key feature of the design is the placement of the amphiphilic and the AB(2) functional groups in orthogonal planes.

  DOI：

  10.1021/ol016064b

文献信息

• [EN] BIARYL MONOMERS AND DENDRITIC POLYMERS DERIVED THEREFROM<br/>[FR] MONOMERES BIARYLES ET POLYMERES DENDRITIQUES DERIVES
  申请人：UNIV TULANE

  公开号：WO2002077037A2

  公开（公告）日：2002-10-03

  Globular dendritic polymers having functional groups oriented on the exterior and interior surfaces of the polymer are disclosed (Fig 1). The inventive polymers are composed of biaryl monomer units having at least two substituents. One of the substituents orients toward the exterior surface of the globular dendritic polymer and the other substituent orients toward the interior surface of the polymer. Each substituent can be selected to have an affinity for a solvent having a particular solvent property, such as, for example, hydrophobicity, hydrophilicity, solvent polarity, pH, ionic strength. When the polymer is dissolved in a solvent having a solvent having a solvent parameter for which a substituent has an affinity, that substituent orients toward the external surface of the polymer. When one substituent is hydrophilic and one substituent is hydrophobic, the polymers are facially amphiphilic. The dendeitic polymers are useful for encapsulation and controlled release of phamraceutical and agrochemical agents, catalysis, and targeted drug delivery.