(S)-1-phenylseleno-3-(2',4'-dimethoxyphenyl)-3-phenylpropane | 251317-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-phenylseleno-3-(2',4'-dimethoxyphenyl)-3-phenylpropane
• 英文别名: 2,4-dimethoxy-1-[(1S)-1-phenyl-3-phenylselanylpropyl]benzene
• CAS: 251317-24-5
• 化学式: C₂₃H₂₄O₂Se
• 分子量: 411.402
• InChiKey: XBPSCJUPTJYAHI-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.67
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-1-phenylseleno-3-(2',4'-dimethoxyphenyl)-3-phenylpropane 在 sodium periodate 、 碳酸氢钠 作用下， 以 甲醇 、 水 为溶剂， 以100%的产率得到(S)-3-(2',4'-dimethoxyphenyl)-3-phenyl-1-propene
  参考文献：
  名称：

  Stereoselective Synthesis of (R)- and (S)-4-Methoxydalbergione via Asymmetric Catalytic Hydrogenation

  摘要：

  [GRAPHICS](R)-(+)- and (S)-(-)-4-methoxydalbergione were synthesized in seven steps with an enantiomeric excess of up to 95% using an asymmetric catalytic hydrogenation step with [Rh((S,S)-bdpp)(NBD)]ClO4 or [Rh((R,R)-bdpp)(NBD)]ClO4, respectively, at a hydrogen pressure of 80 bar. This method should give an easy access to the other members of the dalbergione family.

  DOI：

  10.1021/ol990961m
• 作为产物：
  描述：

  3-(2-羟基-4-甲氧基苯基)-3-苯基烯丙醇 在 [Rh((R,R)-bdpp)(NBD)]ClO₄ 三丁基膦 、 氢气 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 丙酮 为溶剂， 反应 170.0h， 生成 (S)-1-phenylseleno-3-(2',4'-dimethoxyphenyl)-3-phenylpropane
  参考文献：
  名称：

  Stereoselective Synthesis of (R)- and (S)-4-Methoxydalbergione via Asymmetric Catalytic Hydrogenation

  摘要：

  [GRAPHICS](R)-(+)- and (S)-(-)-4-methoxydalbergione were synthesized in seven steps with an enantiomeric excess of up to 95% using an asymmetric catalytic hydrogenation step with [Rh((S,S)-bdpp)(NBD)]ClO4 or [Rh((R,R)-bdpp)(NBD)]ClO4, respectively, at a hydrogen pressure of 80 bar. This method should give an easy access to the other members of the dalbergione family.

  DOI：

  10.1021/ol990961m

文献信息

• Stereoselective Synthesis of (<i>R</i>)- and (<i>S</i>)-4-Methoxydalbergione via Asymmetric Catalytic Hydrogenation
  作者：Philippe Bissel、Abdesslame Nazih、Rafaël Sablong、Jean-Pierre Lepoittevin

  DOI：10.1021/ol990961m

  日期：1999.10.1

  [GRAPHICS](R)-(+)- and (S)-(-)-4-methoxydalbergione were synthesized in seven steps with an enantiomeric excess of up to 95% using an asymmetric catalytic hydrogenation step with [Rh((S,S)-bdpp)(NBD)]ClO4 or [Rh((R,R)-bdpp)(NBD)]ClO4, respectively, at a hydrogen pressure of 80 bar. This method should give an easy access to the other members of the dalbergione family.