3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropenone | 125553-68-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropenone
• 英文别名: (Z)-3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one
• CAS: 125553-68-6
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: RSBPJMGTKUPTBM-UVTDQMKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2-羟基-4-甲氧基苯基)-3-苯基丙烷-1,3-二酮 以 氘代氯仿 为溶剂， 生成 3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropenone 、
  参考文献：
  名称：

  Cunningham, Bernadette D. M.; Lowe, Philip R.; Threadgill, Michael D., Journal of the Chemical Society. Perkin transactions II, 1989, p. 1275 - 1284

  摘要：

  DOI：

文献信息

• AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF
  申请人：Candau Didier

  公开号：US20090074820A1

  公开（公告）日：2009-03-19

  The invention relates to the use of at least one agent for screening out light radiation with a wavelength ranging from 370 to 500 nm as an agent for inhibiting the degradation of endogenous carotenoids present in the skin. The invention is useful for treating skin disorders caused by sunlight (e.g., solar urticaria, actinic dermatitis and pigmentation marks). The invention also relates to novel aminoaryl-vinyl-s-triazine compounds and to the use thereof as agents for screening out light radiation ranging from 370 to 500 nm.

  本发明涉及使用至少一种筛选波长在370至500纳米范围内的光辐射的药剂作为抑制皮肤内源类胡萝卜素降解的药剂。本发明对于治疗由阳光引起的皮肤疾病（例如太阳性荨麻疹、光化性皮炎和色素斑）非常有用。本发明还涉及新的氨基芳基乙烯基-s-三嗪化合物及其作为筛选波长在370至500纳米范围内的光辐射的药剂的用途。
• Compositions cosmétiques antisolaires à base d'un mélange synergique de filtres et utilisations
  申请人：L'Oréal

  公开号：EP2196189A1

  公开（公告）日：2010-06-16

  L'invention concerne de nouvelles compositions cosmétiques ou dermatologiques à usage topique, en particulier pour la photoprotection de la peau et/ou des cheveux, caractérisées par le fait qu'elles comprennent, dans un support cosmétiquement acceptable, au moins : (a) à titre de premier filtre un filtre UV organique, insoluble, de taille de particule allant de 10 nm à 5 µm et choisi parmi les filtres UV organiques du type oxalanilide ; du type triazine ; du type amide vinylique ; du type cinnamamide ; du type comportant un ou plusieurs groupements benzazole et/ou benzofuranne, benzothiophène ou du type indole ; du type aryl vinylène cétone ; du type dérivé de phénylène bis-benzoxazinone du type dérivé amide, sulfonamide ou carbamate d'acrylonitrile et (b) un dérivé de 2-hydroxybenzophénone amino-substitué particulier, à titre de second filtre. L'invention concerne également leurs applications à la protection de la peau et des cheveux contre les effets du rayonnement ultraviolet.

  本发明涉及外用的新型化妆品或皮肤科组合物，特别是用于皮肤和/或头发的光保护，其特征在于，它们在化妆品可接受的支持物中至少包括： (a) 作为第一屏蔽剂，粒径在 10 纳米到 5 微米之间的不溶性有机紫外线屏蔽剂， 选自草酰苯胺类、三嗪类、乙烯基酰胺类、肉桂酰胺类......；含有一个或多个苯甲唑和/或苯并呋喃、苯并噻吩或吲哚基团的类型； 芳基乙烯酮类型；苯基双苯并恶嗪酮衍生物类型；丙烯腈酰胺、磺酰胺或氨基甲酸 酯衍生物类型；以及 (b) 一种特殊的氨基取代的 2-羟基二苯甲酮衍生物，作为第二过滤器。 本发明还涉及它们在保护皮肤和头发免受紫外线辐射影响方面的应用。
• COSMETIC COMPOSITION CONTAINING SCREENING COMPOSITE PARTICLES
  申请人：L'Oréal

  公开号：EP2872107B1

  公开（公告）日：2021-07-21
• COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES
  申请人：Shimizu Momoko

  公开号：US20150157539A1

  公开（公告）日：2015-06-11

  The present invention relates to a cosmetic composition comprising, at least: (i) at least one composite pigment comprising: at least one small particle with a mean particle size of more than 100 nm and less than 1 um, preferably less than 600 nm, and more preferably less than 400 nm, wherein the surface of the small particle is at least in part covered with at least one coating layer comprising at least one inorganic or organic solid UV filter, and optionally at least one coloring agent, preferably at least one coating layer comprising at least one inorganic or organic solid UV filter, and more preferably at least one inorganic solid UV filter; and (ii) at least one plate-type filler with a refractive index of more than 1.6 and less than 2.2 in an amount of more than 1% by weight relative to the total weight of composition.
• COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES
  申请人：Tachon Romain

  公开号：US20150190320A1

  公开（公告）日：2015-07-09

  The present invention relates to a cosmetic composition comprising, at least: (i) at least one composite pigment comprising at least one small particle with a mean particle size of more than 100 nm and less than 1 μm, preferably less than 600 nm, and more preferably less than 400 nm, wherein the surface of the small particle is at least in part covered with at least one coating layer comprising at least one inorganic or organic particulate solid UV filter; (ii) at least one organopolysiloxane elastomer; and (iii) at least one oil absorbing agent with oil absorption capability of 1 ml/1 g or more in an amount of more than 1% by weight relative to the total weight of composition.