3-benzamido-3-(4-methoxyphenyl)propanoic acid | 101878-30-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzamido-3-(4-methoxyphenyl)propanoic acid
• 英文别名: 3-benzoylamino-3-(4-methoxy-phenyl)-propionic acid；3-Benzoylamino-3-(4-methoxy-phenyl)-propionsaeure；3-(4-Methoxyphenyl)-3-[(phenylcarbonyl)amino]propanoic acid
• CAS: 101878-30-2
• 化学式: C₁₇H₁₇NO₄
• 分子量: 299.326
• InChiKey: VNRDOHJIAYNFBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-benzamido-3-(4-methoxyphenyl)propanoic acid 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.08h， 以40%的产率得到4-(4-methoxyphenyl)-2-phenyl-4,5-dihydro-1,3-oxazin-6-one
  参考文献：
  名称：

  恶嗪酮的动力学拆分：通过实验设计合理探索化学空间

  摘要：

  对4-取代的恶嗪酮的有机催化动力学拆分进行了优化（选择性因子S最高为98，手性恶嗪酮ee值最高为99.6％（1 a – g），产物ee值最高为90％（3 a – g））。通过应用实验设计（DoE）方法的一种合理方法。

  DOI：

  10.1002/chem.201402380
• 作为产物：
  描述：

  3-氨基-3-(4-甲氧基苯基)丙酸甲酯 在 水 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 sodium hydroxide 作用下， 以 四氯化碳 、 丙酮 为溶剂， 生成 3-benzamido-3-(4-methoxyphenyl)propanoic acid
  参考文献：
  名称：

  Synthesis, in Vitro and in Vivo Biological Evaluation, and Comprehensive Understanding of Structure−Activity Relationships of Dipeptidyl Boronic Acid Proteasome Inhibitors Constructed from β-Amino Acids

  摘要：

  An extensive structure-activity relationship (SAR) study of 72 dipeptidyl boronic acid proteasome inhibitors constructed from beta-amino acids is reported. SAR analysis revealed that bicyclic groups at the RI position, 3-F substituents at the R-2 position, and bulky aliphatic groups at the R-3 position were favorable to the activities. Enzymatic screening results showed that compound 78, comprising all of these features, was the most active inhibitor against the 20S human proteasome at less than a 2 nM level, as active as the marketed drug bortezomib. Cellular assays confirmed that compound 78 was the most potent against two hematologic and some solid tumor cells with IC50 values less than 1 mu M. Pharmacokinetic profiles suggested that 78 showed higher plasma exposure and a longer half-life than bortezomib.

  DOI：

  10.1021/jm1009742

文献信息

• Synthesis, in Vitro and in Vivo Biological Evaluation, Docking Studies, and Structure−Activity Relationship (SAR) Discussion of Dipeptidyl Boronic Acid Proteasome Inhibitors Composed of β-Amino Acids
  作者：Yongqiang Zhu、Xinrong Zhu、Gang Wu、Yuheng Ma、Yuejie Li、Xin Zhao、Yunxia Yuan、Jie Yang、Sen Yu、Feng Shao、Runtao Li、Yanrong Ke、Aijun Lu、Zhenming Liu、Liangren Zhang

  DOI：10.1021/jm901407s

  日期：2010.3.11

  A series of novel dipeptidyl boronic acid proteasome inhibitors composed of beta-amino acids were synthesized, in vitro and in vivo biologically evaluated, and theoretically modeled for the first time. From the screened racemic compounds in enzyme, 4i wits the most active. The IC50 value of its pure enantiomer 4q was 9.6 nM, 36-fold more active than its isomer 4p and as active its the marketed bortezomib in inhibiting human 20S proteasome. This candidate also showed good activities with IC50 values nearly less than 5 mu M against several human solid and hematologic tumor cell lines. Safety evaluation in vivo with zebrafish and Sprague-Dawley (SD) rats showed that the candidate 4q was less toxic than bortezomib. Pharmacokinetic profiles suggested candidate 4q showed a more plasma exposure and longer half-life than bortezomib. Docking results indicated that 4q nearly interacted with 20S proteasome in it similar way as bortezomib.
• Kinetic Resolution of Oxazinones: An Organocatalytic Approach to Enantiomerically Pure β-Amino Acids
  作者：Albrecht Berkessel、Felix Cleemann、Santanu Mukherjee

  DOI：10.1002/anie.200502003

  日期：2005.11.18
• Kanewskaja; Jaskina, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 68,70; engl. Ausg. S. 77, 79
  作者：Kanewskaja、Jaskina

  DOI：——

  日期：——
• Synthesis, in Vitro and in Vivo Biological Evaluation, and Comprehensive Understanding of Structure−Activity Relationships of Dipeptidyl Boronic Acid Proteasome Inhibitors Constructed from β-Amino Acids
  作者：Yongqiang Zhu、Gang Wu、Xinrong Zhu、Yuheng Ma、Xin Zhao、Yuejie Li、Yunxia Yuan、Jie Yang、Sen Yu、Feng Shao、Meng Lei

  DOI：10.1021/jm1009742

  日期：2010.12.23

  An extensive structure-activity relationship (SAR) study of 72 dipeptidyl boronic acid proteasome inhibitors constructed from beta-amino acids is reported. SAR analysis revealed that bicyclic groups at the RI position, 3-F substituents at the R-2 position, and bulky aliphatic groups at the R-3 position were favorable to the activities. Enzymatic screening results showed that compound 78, comprising all of these features, was the most active inhibitor against the 20S human proteasome at less than a 2 nM level, as active as the marketed drug bortezomib. Cellular assays confirmed that compound 78 was the most potent against two hematologic and some solid tumor cells with IC50 values less than 1 mu M. Pharmacokinetic profiles suggested that 78 showed higher plasma exposure and a longer half-life than bortezomib.
• Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments
  作者：Polyssena Renzi、Christel Kronig、Armando Carlone、Serap Eröksüz、Albrecht Berkessel、Marco Bella

  DOI：10.1002/chem.201402380

  日期：2014.9.8

  The organocatalytic kinetic resolution of 4‐substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6 % (1 a–g) and product ee values up to 90 % (3 a–g)) in a rational way by applying the Design of Experiments (DoE) approach.

  对4-取代的恶嗪酮的有机催化动力学拆分进行了优化（选择性因子S最高为98，手性恶嗪酮ee值最高为99.6％（1 a – g），产物ee值最高为90％（3 a – g））。通过应用实验设计（DoE）方法的一种合理方法。