Acetic acid 2-(11-acryloylamino-undecanoylamino)-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-2-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl ester | 151767-52-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Acetic acid 2-(11-acryloylamino-undecanoylamino)-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-2-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl ester
• CAS: 151767-52-1
• 化学式: C₄₈H₇₂N₂O₂₄
• 分子量: 1061.1
• InChiKey: JGVUJDYBWRILOV-HRQPSVPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.42
• 重原子数：
  74.0
• 可旋转键数：
  31.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  331.82
• 氢给体数：
  2.0
• 氢受体数：
  24.0

反应信息

• 作为反应物：
  描述：

  Acetic acid 2-(11-acryloylamino-undecanoylamino)-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-2-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl ester 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Synthèse de glycolipides polymérisables Dérivés du Tris(hydroxyméthyl)aminométhane: Préparation de micelles polymérisées.

  摘要：

  We have synthesized a series of new polymerizable glycolipids derived from Tris(hydroxymethyl) aminomethane (TRIS). Galactosylation of TRIS was performed in good yield by means of ultrasounds. Polymerization of 11-N-acrylamido-N-Tris(beta-D-galactopyranosyl oxymethyl)methyl undecanamide in aqueous solution by UV irradiation, led to polymerized micellar structures (A).

  DOI：

  10.1016/s0040-4039(00)60523-3
• 作为产物：
  描述：

  11-N-acylamido-N-tris(hydroxymethyl)methyl undecanamide 在 吡啶 、 氰化汞 、 对甲苯磺酸 、 溶剂黄146 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 0.25h， 生成 Acetic acid 2-(11-acryloylamino-undecanoylamino)-3-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-2-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl ester
  参考文献：
  名称：

  Synthèse de glycolipides polymérisables Dérivés du Tris(hydroxyméthyl)aminométhane: Préparation de micelles polymérisées.

  摘要：

  We have synthesized a series of new polymerizable glycolipids derived from Tris(hydroxymethyl) aminomethane (TRIS). Galactosylation of TRIS was performed in good yield by means of ultrasounds. Polymerization of 11-N-acrylamido-N-Tris(beta-D-galactopyranosyl oxymethyl)methyl undecanamide in aqueous solution by UV irradiation, led to polymerized micellar structures (A).

  DOI：

  10.1016/s0040-4039(00)60523-3