5-(furan-3-yl)-1-methyl-1H-indole | 1247825-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(furan-3-yl)-1-methyl-1H-indole
• 英文别名: 5-(Furan-3-yl)-1-methylindole
• CAS: 1247825-79-1
• 化学式: C₁₃H₁₁NO
• 分子量: 197.236
• InChiKey: WGKAYCVPWBYEJO-UHFFFAOYSA-N

物化性质

• 沸点：
  362.2±25.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  18.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-(furan-3-yl)-1-methyl-1H-indole 在 sodium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成 1-methyl-3-((trifluoromethyl)thio)-5-(2-((trifluoromethyl)thio)furan-3-yl)-1H-indole
  参考文献：
  名称：

  Sodium Chloride Catalyzed Regioselective Trifluoromethylthiolation of Furans

  摘要：

  Here, we report the catalytic trifluoromethylthiolation of furans employing sodium chloride as an inexpensive, abundant and ecologically friendly catalyst. The developed method exhibits perfect regioselectivity and a high functional group tolerance. Furthermore, the robustness of the newly developed method was determined by the additive-based Robustness Screen.

  DOI：

  10.1055/s-0036-1588609
• 作为产物：
  描述：

  5-溴-1-甲基吲哚 、 3-呋喃硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 甲醇 、 水 、 甲苯 为溶剂， 反应 16.0h， 以63%的产率得到5-(furan-3-yl)-1-methyl-1H-indole
  参考文献：
  名称：

  Sodium Chloride Catalyzed Regioselective Trifluoromethylthiolation of Furans

  摘要：

  Here, we report the catalytic trifluoromethylthiolation of furans employing sodium chloride as an inexpensive, abundant and ecologically friendly catalyst. The developed method exhibits perfect regioselectivity and a high functional group tolerance. Furthermore, the robustness of the newly developed method was determined by the additive-based Robustness Screen.

  DOI：

  10.1055/s-0036-1588609

文献信息

• Plasminogen Activator Inhibitor-1 Inhibitor
  申请人：Miyata Toshio

  公开号：US20120022080A1

  公开（公告）日：2012-01-26

  The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.

  本发明提供了一种具有纤溶酶原激活物抑制剂-1抑制活性的新化合物，以及包括该化合物作为活性成分的PAI-1抑制剂。本发明还提供了一种对PAI-1活性具有抑制作用且在预防和治疗与PAI-1活性相关的各种疾病方面有效的药物组合物。
• PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR
  申请人：RENASCIENCE CO., LTD.

  公开号：US20140296256A1

  公开（公告）日：2014-10-02

  The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.

  本发明提供了一种具有纤溶酶原激活抑制剂-1抑制活性的新型化合物，以及以该化合物为活性成分的PAI-1抑制剂。本发明还提供了一种具有抑制PAI-1活性并在预防和治疗与PAI-1活性相关的各种疾病方面具有疗效的药物组合物。
• US8785473B2
  申请人：——

  公开号：US8785473B2

  公开（公告）日：2014-07-22
• Sodium Chloride Catalyzed Regioselective Trifluoromethylthiolation of Furans
  作者：Frank Glorius、Johannes Ernst、Lena Rakers

  DOI：10.1055/s-0036-1588609

  日期：——

  Here, we report the catalytic trifluoromethylthiolation of furans employing sodium chloride as an inexpensive, abundant and ecologically friendly catalyst. The developed method exhibits perfect regioselectivity and a high functional group tolerance. Furthermore, the robustness of the newly developed method was determined by the additive-based Robustness Screen.