Fmoc-Gly-Asp(tBu)-Ser(tBu)-Lys(Z)-OMe | 442663-76-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Gly-Asp(tBu)-Ser(tBu)-Lys(Z)-OMe
• 英文别名: Fmoc-Gly-Asp(OtBu)-Ser(tBu)-Lys(Cbz)-OMe；methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoyl]amino]-3-[(2-methylpropan-2-yl)oxy]propanoyl]amino]-6-(phenylmethoxycarbonylamino)hexanoate
• CAS: 442663-76-5
• 化学式: C₄₇H₆₁N₅O₁₂
• 分子量: 888.028
• InChiKey: WBPKYCFJCURZEM-QXUSSCGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  64
• 可旋转键数：
  27
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  226
• 氢给体数：
  5
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  Fmoc-Gly-Asp(tBu)-Ser(tBu)-Lys(Z)-OMe 在 哌啶 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Boc-Arg(Mtr)-Gly-Asp(tBu)-Ser(tBu)-Lys(Z)-OMe
  参考文献：
  名称：

  In vitro and in vivo evaluations of THAM derived telomers bearing RGD and Ara-C for tumour neovasculature targeting

  摘要：

  As an approach to the development of specific drug delivery systems, a new class of low macromolecular carriers called 'telomers' endowed with an antitumour agent, such as arabinofuranosylcytosine (Ara-C), RGDSK peptidic sequences, as tumour targeting moieties, and tyrosine groups labelled with I-125 atoms allowing the in vivo scintigraphic follow up, were synthesized. Their tumour targeting ability was assessed in vivo in mice bearing a murine B16 melanoma. The biological results showed that the presence of RGDSK sequences onto the macromolecules leads to the selective targeting and the accumulation of telomers within the vascularized zone of the tumour. Moreover, such compounds exhibited in vitro a better IC50 (0.015 muM) than pure Ara-C and in vivo an oncostatic index higher than 160%. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0223-5234(03)00150-8
• 作为产物：
  描述：

  FMOC-L-天冬氨酸-β-叔丁酯-Alpha-五氟苯酯 在 哌啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 Fmoc-Gly-Asp(tBu)-Ser(tBu)-Lys(Z)-OMe
  参考文献：
  名称：

  In vitro and in vivo evaluations of THAM derived telomers bearing RGD and Ara-C for tumour neovasculature targeting

  摘要：

  As an approach to the development of specific drug delivery systems, a new class of low macromolecular carriers called 'telomers' endowed with an antitumour agent, such as arabinofuranosylcytosine (Ara-C), RGDSK peptidic sequences, as tumour targeting moieties, and tyrosine groups labelled with I-125 atoms allowing the in vivo scintigraphic follow up, were synthesized. Their tumour targeting ability was assessed in vivo in mice bearing a murine B16 melanoma. The biological results showed that the presence of RGDSK sequences onto the macromolecules leads to the selective targeting and the accumulation of telomers within the vascularized zone of the tumour. Moreover, such compounds exhibited in vitro a better IC50 (0.015 muM) than pure Ara-C and in vivo an oncostatic index higher than 160%. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0223-5234(03)00150-8