ChemBridge ID 7882458 | 709003-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ChemBridge ID 7882458
• 英文别名: 4-(4-(Naphthalen-2-yl)thiazol-2-ylamino)phenol；4-[(4-naphthalen-2-yl-1,3-thiazol-2-yl)amino]phenol
• CAS: 709003-71-4
• 化学式: C₁₉H₁₄N₂OS
• 分子量: 318.399
• InChiKey: MLBSVOUQVBGEQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(对羟基苯基)-2-硫脲 、 2-溴代-2-乙酰基萘 以 乙醇 为溶剂， 生成 ChemBridge ID 7882458
  参考文献：
  名称：

  2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

  摘要：

  Valosin-containing protein (VCP; also known as p97) is a member of the AAA ATPase family with a central role in the ubiquitin-degradation of misfolded proteins. VCP also exhibits antiapoptotic function and metastasis via activation of nuclear factor kappa-B signaling pathway. We have discovered that 2-anilino-4-aryl-1,3-thiazoles are potent drug-like inhibitors of this enzyme. The identified compounds show low nanomolar VCP potency, demonstrate SAR trends, and show activity in a mechanism based cellular assay. This series of compounds represents the first steps towards a novel, small molecule VCP inhibitor as a cancer therapeutic. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.058

文献信息

• Compounds and Uses Thereof in Modulating Amyloid Beta
  申请人：Cheng Soan

  公开号：US20070260058A1

  公开（公告）日：2007-11-08

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新的化合物、组合物和试剂盒。还提供了调节Aβ水平的方法以及治疗与异常Aβ水平相关的疾病的方法。
• COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA
  申请人：Cheng Soan

  公开号：US20100324032A1

  公开（公告）日：2010-12-23

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新型化合物、组合物和试剂盒。还提供了调节Aβ水平的方法和治疗与异常Aβ水平相关的疾病的方法。
• US7781442B2
  申请人：——

  公开号：US7781442B2

  公开（公告）日：2010-08-24
• US8017629B2
  申请人：——

  公开号：US8017629B2

  公开（公告）日：2011-09-13