2-ethoxy-4-nitroso-phenol | 88331-63-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-ethoxy-4-nitroso-phenol
• 英文别名: 2-Aethoxy-4-nitroso-phenol；2-Ethoxy-4-nitrosophenol
• CAS: 88331-63-9
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: QNKIKQWZHHJVEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-ethoxy-4-nitroso-phenol 在 palladium 10% on activated carbon 、 potassium carbonate 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 2-[(4-decyloxy-3-ethoxy-phenylamino)-methylene]-malonic acid diethyl ester
  参考文献：
  名称：

  Synthesis and Anticoccidial Activities of Quinoline Carboxylate Derivatives with Methyl (E)-2-(3-methoxy)acrylate Moiety

  摘要：

  设计并合成了一系列具有甲基(E)-2-(3-甲氧基)丙烯酸酯基团的新型喹啉羧酸衍生物作为抗球虫药物。通过1H NMR、IR和HR-MS光谱确认了其结构。根据抗球虫指数方法初步评估了生物活性。结果表明，这些化合物（7c、7d、7e、7g）对柔嫩艾美耳球虫具有抗球虫活性。特别是，6-癸氧基-7-乙氧基-4-{6-[2-(2-甲氧基-1-甲氧羰基-乙烯基)苯氧基]嘧啶-4-氧基}-喹啉-3-羧酸乙酯（7e）的抗球虫指数为168.7，表明该化合物具有良好的抗球虫活性。

  DOI：

  10.14233/ajchem.2013.14806
• 作为产物：
  描述：

  邻乙氧基苯酚 在 potassium nitrite 、 溶剂黄146 作用下， 生成 2-ethoxy-4-nitroso-phenol
  参考文献：
  名称：

  Pfob, Monatshefte fur Chemie, 1897, vol. 18, p. 469

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• Pfob, Monatshefte fur Chemie, 1897, vol. 18, p. 469
  作者：Pfob

  DOI：——

  日期：——
• Synthesis and Anticoccidial Activities of Quinoline Carboxylate Derivatives with Methyl (E)-2-(3-methoxy)acrylate Moiety
  作者：Yuan Liu、Ya-Biao Weng、Zhao-Bing Chen、Yu-Liang Wang

  DOI：10.14233/ajchem.2013.14806

  日期：——

  A series of novel quinoline carboxylate derivatives with methyl (E)-2-(3-methoxy) acrylate group were designed and synthesized as anticoccidial medicines. The structures were confirmed by 1H NMR, IR and HR-MS spectra. The biological activities were primarily evaluated according to the anticoccidial index method. The results indicated that these compounds (7c, 7d, 7e, 7g) exhibited anticoccidial activities against Eimeria tenella. In particular, the anticoccidial index of 6-decyloxy-7-ethoxy-4-6-[2-(2-methoxy-1-methoxycarbonyl-vinyl)phenoxy]pyrimidin-4-yloxy}-quinoline-3-carboxylic acid ethyl ester (7e) was 168.7, which indicated that the compound has a good anticoccidial activity.

  设计并合成了一系列具有甲基(E)-2-(3-甲氧基)丙烯酸酯基团的新型喹啉羧酸衍生物作为抗球虫药物。通过1H NMR、IR和HR-MS光谱确认了其结构。根据抗球虫指数方法初步评估了生物活性。结果表明，这些化合物（7c、7d、7e、7g）对柔嫩艾美耳球虫具有抗球虫活性。特别是，6-癸氧基-7-乙氧基-4-6-[2-(2-甲氧基-1-甲氧羰基-乙烯基)苯氧基]嘧啶-4-氧基}-喹啉-3-羧酸乙酯（7e）的抗球虫指数为168.7，表明该化合物具有良好的抗球虫活性。