(E)-1-(1-piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one | 1295515-28-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-1-(1-piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one
• 英文别名: (E)-1-piperidin-1-yl-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one
• CAS: 1295515-28-4
• 化学式: C₁₅H₁₆F₃NO₂
• 分子量: 299.293
• InChiKey: NQGJZABQSUETFN-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  哌啶 、 (E)-3-(4-(trifluoromethoxy)phenyl)acrylic acid 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以73%的产率得到(E)-1-(1-piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one
  参考文献：
  名称：

  Synthesis of a Combinatorial Library of Amides and Its Evaluation against the Fall Armyworm, Spodoptera frugiperda

  摘要：

  The fall armyworm Spodoptera frugiperda is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work we describe the preparation of an indexed combinatorial library of amides and its toxic effect by contact against S. frugiperda . (E)-1-(1-Piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one was the most active compound with an LD(50) = 0.793 mu g mg(-1) of larva. This amide was also evaluated by ingestion and at the lowest concentration (1 mg kg(-1)) achieved 83.3% mortality.

  DOI：

  10.1021/jf104903t

文献信息

• Synthesis of a Combinatorial Library of Amides and Its Evaluation against the Fall Armyworm, Spodoptera frugiperda
  作者：Thais C. Castral、Andreia P. Matos、Julia L. Monteiro、Fernanda M. Araujo、Tatiani M. Bondancia、Luciane G. Batista-Pereira、João B. Fernandes、Paulo C. Vieira、M. Fatima G. F. da Silva、Arlene G. Corrêa

  DOI：10.1021/jf104903t

  日期：2011.5.11

  The fall armyworm Spodoptera frugiperda is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work we describe the preparation of an indexed combinatorial library of amides and its toxic effect by contact against S. frugiperda . (E)-1-(1-Piperidinyl)-3-[4-(trifluoromethoxy)phenyl]-2-propen-1-one was the most active compound with an LD(50) = 0.793 mu g mg(-1) of larva. This amide was also evaluated by ingestion and at the lowest concentration (1 mg kg(-1)) achieved 83.3% mortality.