3-ethoxy-4-methoxythiobenzamide | 60758-99-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-ethoxy-4-methoxythiobenzamide
• 英文别名: 3-Ethoxy-4-methoxybenzothioamide；3-ethoxy-4-methoxybenzenecarbothioamide
• CAS: 60758-99-8
• 化学式: C₁₀H₁₃NO₂S
• 分子量: 211.285
• InChiKey: MXIYVKRKPARNJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  硝呋美隆 、 3-ethoxy-4-methoxythiobenzamide 以 乙醇 为溶剂， 生成 2-(3-ethoxy-4-methoxyphenyl)-4-(5'-nitro-2'-furyl)thiazole
  参考文献：
  名称：

  Khadse, B. G.; Lokhande, S. R.; Bhamaria, R. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 856 - 860

  摘要：

  DOI：
• 作为产物：
  描述：

  3-ethoxy-4-methoxybenzaldoxime 在 吡啶 、 硫化氢 、 乙酸酐 、 三乙胺 作用下， 生成 3-ethoxy-4-methoxythiobenzamide
  参考文献：
  名称：

  Khadse, B. G.; Lokhande, S. R.; Bhamaria, R. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 856 - 860

  摘要：

  DOI：

文献信息

• Racemic beta-aminosulfone compounds
  申请人：Quimica Sintetica, S.A.

  公开号：US10689332B2

  公开（公告）日：2020-06-23

  It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.

  本发明描述了制备外消旋β-氨基砜（1）的一种工业上可行且有利的工艺，β-氨基砜（1）是制备N-(2-((1S)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲磺酰基)乙基)-2、后者适用于治疗、预防和/或控制银屑病或银屑病关节炎的方法。
• Novel Thiazole Derivatives as Inhibitors of Superoxide Production by Human Neutrophils: Synthesis and Structure-Activity Relationships
  作者：Masatoshi Chihiro、Hisashi Nagamoto、Isao Takemura、Kazuyoshi Kitano、Hajime Komatsu、Kazuo Sekiguchi、Fujio Tabusa、Toyoki Mori、Michiaki Tominaga、Youichi Yabuuchi

  DOI：10.1021/jm00002a017

  日期：1995.1

  Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4-diethoxyphenyl)thiazol-4-yl]-pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds. The synthesis and structure-activity relationships of these compounds are reported herein.
• KHADSE, B. G.;LOKHANDE, S. R.;BHAMARIA, R. P.;PRABHU, S. R., INDIAN J. CHEM., 26,(1987) N 9, 856-860
  作者：KHADSE, B. G.、LOKHANDE, S. R.、BHAMARIA, R. P.、PRABHU, S. R.

  DOI：——

  日期：——