Z-E(tBu)VD(tBu)-OMe | 206865-05-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-E(tBu)VD(tBu)-OMe
• CAS: 206865-05-6
• 化学式: C₃₁H₄₇N₃O₁₀
• 分子量: 621.728
• InChiKey: GTEUAYKXPHKWMG-HWBMXIPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.93
• 重原子数：
  44.0
• 可旋转键数：
  14.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  175.43
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  Z-E(tBu)VD(tBu)-OMe 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 20.0h， 生成 H-C(Trt)T(tBu)E(tBu)VD(tBu)-OMe
  参考文献：
  名称：

  A Facile Synthetic Method to Prepare Fluorescently Labeled ROMP Polymers

  摘要：

  To probe the activities of sperm ADAM protein (fertilin,6), we devised a general synthetic strategy to generate fluorescently labeled fertilinbeta oligopeptide polymers. Immunofluorescence studies with these polymers demonstrated that fertilinbeta polymers bind specifically to a protein receptor on the mouse egg plasma membrane.

  DOI：

  10.1021/ol048935y
• 作为产物：
  描述：

  L-Asparaginsaeure-α-methylester-β-tert-butylester 在 palladium on activated charcoal 氢气 、 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 Z-E(tBu)VD(tBu)-OMe
  参考文献：
  名称：

  A Facile Synthetic Method to Prepare Fluorescently Labeled ROMP Polymers

  摘要：

  To probe the activities of sperm ADAM protein (fertilin,6), we devised a general synthetic strategy to generate fluorescently labeled fertilinbeta oligopeptide polymers. Immunofluorescence studies with these polymers demonstrated that fertilinbeta polymers bind specifically to a protein receptor on the mouse egg plasma membrane.

  DOI：

  10.1021/ol048935y

文献信息

• Increased Polymer Length of Oligopeptide-Substituted Polynorbornenes with LiCl
  作者：Kenny S. Roberts、Nicole S. Sampson

  DOI：10.1021/jo0265737

  日期：2003.3.1

  The ring-opening metathesis polymerization (ROMP) reaction is extraordinarily useful for the preparation of a large variety of polymers. We report that the length (n = 25-50) of high-substituent-density oligopeptide polymers synthesized by ROMP is dramatically improved upon addition of LiCl to reduce polymer and oligopeptide aggregation. This methodology should significantly expand the variety of polymers that may be prepared by ROMP and be of general use with norbornyl oligopeptides of any sequence.