3,5-dimethylpyrrole-2,4-dicarboxylic acid 4-tert-butyl ester | 528894-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3,5-dimethylpyrrole-2,4-dicarboxylic acid 4-tert-butyl ester
• 英文别名: 3,5-Dimethyl-pyrrol-2,4-dicarbonsaeure-4-tert-butylester；3,5-dimethyl-4-[(2-methylpropan-2-yl)oxycarbonyl]-1H-pyrrole-2-carboxylic acid
• CAS: 528894-82-8
• 化学式: C₁₂H₁₇NO₄
• 分子量: 239.271
• InChiKey: CISNDUQPSDWXAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-dimethylpyrrole-2,4-dicarboxylic acid 4-tert-butyl ester 在 三氟乙酸 、 三氟乙酸酐 作用下， 以 甲苯 为溶剂， 反应 6.5h， 生成
  参考文献：
  名称：

  Synthesis and pharmacological characterisation of 2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists

  摘要：

  Metabotropic glutamate receptors (mGluRs) are an unusual family of G-protein coupled receptor (GPCR), and are characterised by a large extracellular N-terminal domain that contains the glutamate binding site. We have identified a new class of non-competitive metabotropic glutamate receptor 1 (mGluR1) antagonists, 2,4-dicarboxy-pyrroles which are endowed with nano-molar potency. They interact within the 7 transmembrane (7TM) domain of the receptor and show antinociceptive properties when tested in a number of different animal models. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00424-8
• 作为产物：
  描述：

  乙酰乙酸叔丁酯 在 sodium hydroxide 、 溶剂黄146 、 锌 作用下， 生成 3,5-dimethylpyrrole-2,4-dicarboxylic acid 4-tert-butyl ester
  参考文献：
  名称：

  What Happens to the State in Conflict?: Political Analysis as a Tool for Planning Humanitarian Assistance

  摘要：

  It is now part of received wisdom that humanitarian assistance in conflict and post‐conflict situations may be ineffective or even counterproductive in the absence of an informed understanding of the broader political context in which so‐called ‘complex political emergencies’ (CPEs) occur. Though recognising that specific cases have to be understood in their own terms, this article offers a framework for incorporating political analysis in policy design. It is based on a programme of research on a number of countries in Africa and Asia over the last four years. It argues that the starting‐point should be an analysis of crises of authority within contemporary nation‐states which convert conflict (a feature of all political systems) into violent conflict; of how such conflict may in turn generate more problems for, or even destroy, the state; of the deep‐rooted political, institutional and developmental legacies of political violence; and of the difficulties that complicate the restoration of legitimate and effective systems of governance after the ‘termination’ of conflict. It then lists a series of questions which such an analysis would need to ask — less in order to provide a comprehensive check‐list than to uncover underlying political processes and links. It is hoped these may be used not only to understand the political dynamics of emergencies, but also to identify what kinds of policy action should and should not be given priority by practitioners.

  DOI：

  10.1111/1467-7717.00150