3,5-二甲基-1H-吡咯-2,4-二羧酸4-叔丁酯2-乙酯 | 361380-77-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 中文名称: 3,5-二甲基-1H-吡咯-2,4-二羧酸4-叔丁酯2-乙酯
• 英文名称: 3,5-dimethyl-pyrrole-2,4-dicarboxylic acid 4-tert-butyl ester 2-ethyl ester
• 英文别名: 3,5-dimethyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-tert-butyl ester；3,5-Dimethyl-pyrrol-2,4-dicarbonsaeure-2-aethylester-4-tert-butylester；4-tert-butyl-2-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate；4-Tert-butyl 2-ethyl 3,5-dimethyl-1h-pyrrole-2,4-dicarboxylate；4-O-tert-butyl 2-O-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
• CAS: 361380-77-0
• 化学式: C₁₄H₂₁NO₄
• 分子量: 267.325
• InChiKey: XTQZSZZJWWUQON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  3,5-二甲基-1H-吡咯-2,4-二羧酸4-叔丁酯2-乙酯 在 溶剂黄146 作用下， 生成 2,4-二甲基-5-乙氧羰基-3-吡咯甲酸
  参考文献：
  名称：

  What Happens to the State in Conflict?: Political Analysis as a Tool for Planning Humanitarian Assistance

  摘要：

  It is now part of received wisdom that humanitarian assistance in conflict and post‐conflict situations may be ineffective or even counterproductive in the absence of an informed understanding of the broader political context in which so‐called ‘complex political emergencies’ (CPEs) occur. Though recognising that specific cases have to be understood in their own terms, this article offers a framework for incorporating political analysis in policy design. It is based on a programme of research on a number of countries in Africa and Asia over the last four years. It argues that the starting‐point should be an analysis of crises of authority within contemporary nation‐states which convert conflict (a feature of all political systems) into violent conflict; of how such conflict may in turn generate more problems for, or even destroy, the state; of the deep‐rooted political, institutional and developmental legacies of political violence; and of the difficulties that complicate the restoration of legitimate and effective systems of governance after the ‘termination’ of conflict. It then lists a series of questions which such an analysis would need to ask — less in order to provide a comprehensive check‐list than to uncover underlying political processes and links. It is hoped these may be used not only to understand the political dynamics of emergencies, but also to identify what kinds of policy action should and should not be given priority by practitioners.

  DOI：

  10.1111/1467-7717.00150
• 作为产物：
  描述：

  乙酰乙酸乙酯 在 溶剂黄146 、 锌 、 sodium nitrite 作用下， 反应 2.5h， 生成 3,5-二甲基-1H-吡咯-2,4-二羧酸4-叔丁酯2-乙酯
  参考文献：
  名称：

  [EN] NOVEL FUSED PYRIDAZINE DERIVATIVES
  [FR] NOUVEAUX DÉRIVÉS PYRIDAZINE FUSIONNÉS

  摘要：

  本发明涉及新型融合吡啶嗪化合物，其药学上可接受的盐，以及其异构体、立体异构体、构象异构体、互变异构体、多型、水合物和溶剂合物。本发明还涵盖所述化合物的药学上可接受的组合物和制备新型化合物的方法。该发明还涉及上述化合物用于制备用作药物的药物的用途。

  公开号：

  WO2011048611A1

文献信息

• Treibs; Hintermeier, Justus Liebigs Annalen der Chemie, 1955, vol. 592, p. 11,25
  作者：Treibs、Hintermeier

  DOI：——

  日期：——
• Treibs; Hintermeier, Justus Liebigs Annalen der Chemie, 1957, vol. 605, p. 35,42
  作者：Treibs、Hintermeier

  DOI：——

  日期：——
• [EN] TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA TYROSINE KINASE
  申请人：MERCK & CO INC

  公开号：WO2003035614A2

  公开（公告）日：2003-05-01

  The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a 2-carboxy-5-formyl pyrrole. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.