2-Bromo-1-oxo-1,2,3,4-tetrahydrophenanthrene | 79074-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 2-Bromo-1-oxo-1,2,3,4-tetrahydrophenanthrene
• 英文别名: 2-bromo-3,4-dihydro-2H-phenanthren-1-one；2-Brom-3,4-dihydro-2H-phenanthren-1-on；2-Bromo-1,2,3,4-tetrahydrophenanthren-1-one；2-bromo-3,4-dihydro-2H-phenanthren-1-one
• CAS: 79074-27-4
• 化学式: C₁₄H₁₁BrO
• 分子量: 275.145
• InChiKey: KKFJYTICKPMJQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  哌啶 、 2-Bromo-1-oxo-1,2,3,4-tetrahydrophenanthrene 在 苯 作用下， 生成 2-piperidino-3,4-dihydro-2H-phenanthren-1-one
  参考文献：
  名称：

  Studies in the Phenanthrene Series. IX. Amino Alcohols Derived from 1,2,3,4-Tetrahydrophenanthrene¹

  摘要：

  DOI：

  10.1021/ja01314a046
• 作为产物：
  描述：

  4-(1-naphthyl)butanoic acid 在 溴 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 2-Bromo-1-oxo-1,2,3,4-tetrahydrophenanthrene
  参考文献：
  名称：

  Kumar, Satish; Sharma, K. S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 5, p. 380 - 383

  摘要：

  DOI：

文献信息

• Condensed thiazole derivative, production process thereof and
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US05565479A1

  公开（公告）日：1996-10-15

  Condensed thiazole derivatives useful as 5-HT.sub.3 receptor agonists are provided and can be represented by the following formula (I) or a pharmaceutically acceptable salt thereof, a process for the production thereof and a pharmaceutical composition thereof: ##STR1## wherein R, A, L.sub.1, L.sub.2, L, and R.sup.1 -R.sup.6 are defined herein and Im represents a group of the formula: ##STR2##

  提供了作为5-HT.sub.3受体激动剂有用的缩合噻唑衍生物，可以用以下公式(I)或其药学上可接受的盐来表示，其制备过程和药物组成物如下： ##STR1## 其中R，A，L.sub.1，L.sub.2，L和R.sup.1-R.sup.6在此定义，Im表示以下公式的一个基团： ##STR2##
• NOVEL CONDENSED THIAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0666263A1

  公开（公告）日：1995-08-09

  A condensed thiazole derivative useful as a 5-HT₃ receptor agonist, represented by general formula (I), a pharmaceutically acceptable salt thereof, a process for producing the same, and a pharmaceutical composition containing the same, wherein R represents hydrogen, halogen, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, nitro, amino, cyano or protected hydroxy; A represents a benzene or naphthalene ring; one of L₁ and L₂ represents a mere bond while the other then represents: (a) linear or branched lower alkylene which may be interrupted by oxygen or sulfur, (b) oxygen or sulfur, or (c) lower alkenylene; L represents a mere bond, or linear or branched lower alkylene; Im represents α or β; R¹, R² and R³ may be the same or different from one another and each represents hydrogen or lower alkyl; and R⁴, R⁵ and R⁶ may be the same or different from one another and each represents hydrogen or lower alkyl.

  一种可用作 5-HT₃ 受体激动剂的缩合噻唑衍生物，由通式(I)、其药学上可接受的盐、生产该衍生物的工艺以及含有该衍生物的药物组合物表示，其中 R 代表氢、卤素、羟基、低级烷氧基、羧基、低级烷氧基羰基、硝基、氨基、氰基或受保护的羟基；A 代表苯环或萘环； L₁ 和 L₂ 中的一个代表单纯的键，而另一个则代表(a) 可被氧或硫打断的直链或支链低级亚烷基，(b) 氧或硫，或 (c) 低级烯基；L 代表纯键，或直链或支链低级亚烷基；Im 代表 α 或 β；R¹、R² 和 R³ 可彼此相同或不同，且各自代表氢或低级烷基；以及 R⁴、R⁵ 和 R⁶ 可彼此相同或不同，且各自代表氢或低级烷基。
• Dannenberg; Dannenberg-v. Dresler, Zeitschrift fur Naturforschung, 1952, vol. 7b, p. 265,267
  作者：Dannenberg、Dannenberg-v. Dresler

  DOI：——

  日期：——
• The Synthesis of 2'-Ketodihydro-1,2-cyclopentenophenanthrene and Derivatives of Phenanthro [1,2-b] furan
  作者：A. L. Wilds

  DOI：10.1021/ja01258a050

  日期：1942.6
• Tetrathiafulvalene. XXVII [1] Darstellung und Eigenschaften cis- und trans-isomerer Dihydrophenanthreno-Tetrathiafulvalene
  作者：E. Fangh�nel、L. van Hinh、G. Schukat

  DOI：10.1002/prac.19933350705

  日期：——

  The synthesis of anellated tetrathiafulvalenes (TTF) 10a-c, 11a-b via the 1,3-dithiolium salt/triethylamin or 1,3-dithiole-2-thione/triethyl phosphite route is described. The dihydrophenanthreno-anellated TITs 10a, b can be thermally transformed into the phenanthreno-anellated TTFs 11a, b. Only in the case of the dihydrophenanthreno-anellated TTF 10b (with ''alpha-naphthyl structure'') the isolation of the cis- and trans-isomer was possible due to differences in the solubility. Starting from the pure cis- or trans-isomer the radical salts of 10b are reducible to a 1 : 1 mixture of the cis/trans stereo isomers. The spectroscopic, electrochemical, and conductivity properties of the synthesized TTFs and their complexes with iodine, TCNQ, and DDQ are described.