(-)-deoxyradicinin | 84413-76-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (-)-deoxyradicinin
• 英文别名: deoxyradicinin；Deoxyradicinin；(2S)-2-methyl-7-[(E)-prop-1-enyl]-2,3-dihydropyrano[3,2-c]pyran-4,5-dione
• CAS: 84413-76-3
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: SHGIAYIFKLLQOL-SDLBARTOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-[(E)-2-butenoyl]-4-methoxy-6-[(E)-1-propenyl]-2H-pyran-2-one 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以1.8 mg的产率得到(-)-deoxyradicinin
  参考文献：
  名称：

  Conversions of deoxyradicinin to radicinin and of radicinin to 3-epi-radicinin in the phytopathogenic fungus Bipolaris coicis

  摘要：

  Radicinin is a phytotoxic and antibiotic metabolite produced by some phytopathogenic fungi. Precursor administration and cell-free experiments with deoxyradicinin and radicinin were carried out in Bipolaris colds H13-3. When deoxyradicinin was administered to the fungus, radicinin and 3-epi-radicinin formed. When radicinin administered, 3-epi-radicinin was formed. Their formation was confirmed by cell-free experiments. Deoxyradicinin 3-monooxygenase which catalyzes conversion of deoxyradicinin to radicinin showed the best activity at 35 degrees C and pH 7.0, and required NAD(+) as co-enzyme. Its molecular weight was determined to be 130-184 kDa. Radicinin epimerase catalyzing the reaction of radicinin to 3-epi-radicinin was purified from a cell-free extract. Radicinin epimerase is a homodimer of a 28 kDa subunit, and its highest activity was achieved at 30-35 degrees C and pH 7.0-9.0. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2011.11.010

文献信息

• Fungi antagonistic to Xylella fastidiosa
  申请人：The Regents of the University of California

  公开号：US10238118B2

  公开（公告）日：2019-03-26

  The disclosure describes fungal organisms and preparations useful for inhibiting infection by Xylella sp. and in the treatment of Pierce's Disease.

  本公开描述了真菌生物和制剂，可用于抑制 Xylella sp.的感染和治疗皮尔斯病。
• FUNGI ANTAGONISTIC TO XYLELLA FASTIDIOSA
  申请人：Rolshausen Philippe

  公开号：US20120282233A1

  公开（公告）日：2012-11-08

  The disclosure describes fungal organisms and preparations useful for inhibiting infection by Xylella sp. and in the treatment of Pierce's Disease.
• US9433219B2
  申请人：——

  公开号：US9433219B2

  公开（公告）日：2016-09-06
• [EN] ORGANISMS ANTAGONISTIC TO XYLELLA FASTIDIOSA<br/>[FR] ORGANISMES ANTAGONISTES DE XYLELLA FASTIDIOSA
  申请人：UNIV CALIFORNIA

  公开号：WO2018144478A1

  公开（公告）日：2018-08-09

  The disclosure describes microorganisms and preparations useful for inhibiting infection by Xylella sp. and in the treatment of Pierce's Disease.