(4-morpholin-4-yl-phenyl)-(5-tributylstannanyl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-carbamic acid tert-butyl ester | 959755-57-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (4-morpholin-4-yl-phenyl)-(5-tributylstannanyl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-carbamic acid tert-butyl ester
• 英文别名: (4-Morpholin-4-yl-phenyl)-(5-tributylstannanyl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-carbamic acid tert-butyl ester；tert-butyl N-(4-morpholin-4-ylphenyl)-N-(5-tributylstannyl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)carbamate
• CAS: 959755-57-8
• 化学式: C₃₂H₅₀N₆O₃Sn
• 分子量: 685.497
• InChiKey: MLUJPEPKCPMUCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.09
• 重原子数：
  42
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  85.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-溴-3,4-二氢-2H-异喹啉-1-酮 、 (4-morpholin-4-yl-phenyl)-(5-tributylstannanyl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-carbamic acid tert-butyl ester 在 四(三苯基膦)钯 silica gel 、 petroleum ether 、 乙酸乙酯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以ethyl acetate and ethyl acetate affords the target compound as a yellow solid (30 mg, 37%)的产率得到(4-morpholin-4-yl-phenyl)-[5-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-6-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases

  摘要：

  本发明揭示了一种Novel [1.2.4]triazolo[1,5-a]pyrazine化合物，其化学式如下：这些化合物可以制备成药物组成物，并可用于哺乳动物包括人类的预防和治疗多种疾病，例如，但不限于疼痛、炎症等。

  公开号：

  US20080090818A1
• 作为产物：
  描述：

  三丁基氯化锡 在 异丙基氯化镁 作用下， 以 四氢呋喃 为溶剂， 反应 0.58h， 以20%的产率得到(4-morpholin-4-yl-phenyl)-(5-tributylstannanyl-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  WO2007/138072

  摘要：

  公开号：

文献信息

• Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases
  申请人：Andrews Inglis Martin James

  公开号：US20080090818A1

  公开（公告）日：2008-04-17

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  本发明揭示了一种Novel [1.2.4]triazolo[1,5-a]pyrazine化合物，其化学式如下：这些化合物可以制备成药物组成物，并可用于哺乳动物包括人类的预防和治疗多种疾病，例如，但不限于疼痛、炎症等。
• Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
  申请人：Galapagos NV

  公开号：US07915256B2

  公开（公告）日：2011-03-29

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  公开了一种Novel [1.2.4]三唑并[1,5-a]吡嗪化合物，其化学式如下所示：这些化合物可以制备成药物组合物，并可用于哺乳动物（包括人类）的预防和治疗多种疾病，例如疼痛、炎症等等。
• TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20100298300A1

  公开（公告）日：2010-11-25

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  本发明披露了一种具有以下公式表示的[1.2.4]三唑并[1,5-a]吡嗪化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于疼痛，炎症等。
• WO2007/138072
  申请人：——

  公开号：——

  公开（公告）日：——
• TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20110178067A1

  公开（公告）日：2011-07-21

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  揭示了一种Novel [1.2.4]三唑并[1,5-a]吡嗪化合物，其化学式如下：这些化合物可以制备为药物组合物，并可用于哺乳动物，包括人类的预防和治疗多种病症，例如疼痛、炎症等，但不限于此。