乙基(5S)-5-氰基-L-脯氨酸酯 | 435274-88-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙基(5S)-5-氰基-L-脯氨酸酯
• 英文名称: ethyl (5S)-5-cyano-L-prolinate
• 英文别名: ethyl (2S,5S)-5-cyanopyrrolidine-2-carboxylate
• CAS: 435274-88-7
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: WGPRYWGHOIXWPQ-BQBZGAKWSA-N

物化性质

• 沸点：
  290.1±40.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙基(5S)-5-氰基-L-脯氨酸酯 在 盐酸 作用下， 反应 12.0h， 以91%的产率得到(2S,5S)-吡咯啉-2,5-二羧酸
  参考文献：
  名称：

  An efficient synthesis of substituted prolines by the selective reduction and reductive cyanation of 2-pyrrolidones

  摘要：

  Substituted pyrrolidones undergo selective reduction using Cp2ZrHCl (Schwartz's reagent) to form Delta(1)-pyrrolines, which can be isolated or directly cyanated and hydrolyzed to the corresponding proline. Short syntheses of glutamic semialdehyde (ethyl ester), the marine metabolite (2S,5S)-pyrrolidine-2,5-dicarboxylic acid, and the conformationally constrained amino acid 5,5-dimethylproline, are reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00097-7
• 作为产物：
  描述：

  L-焦谷氨酸乙酯 、 alkaline earth salt of/the/ methylsulfuric acid 在 Schwartz's reagent 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 乙基(5S)-5-氰基-L-脯氨酸酯
  参考文献：
  名称：

  An efficient synthesis of substituted prolines by the selective reduction and reductive cyanation of 2-pyrrolidones

  摘要：

  Substituted pyrrolidones undergo selective reduction using Cp2ZrHCl (Schwartz's reagent) to form Delta(1)-pyrrolines, which can be isolated or directly cyanated and hydrolyzed to the corresponding proline. Short syntheses of glutamic semialdehyde (ethyl ester), the marine metabolite (2S,5S)-pyrrolidine-2,5-dicarboxylic acid, and the conformationally constrained amino acid 5,5-dimethylproline, are reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00097-7

文献信息

• Imidazothiazole derivatives
  申请人：Kawato Haruko

  公开号：US20090312310A1

  公开（公告）日：2009-12-17

  There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R 1 , R 2 , R 3 , R 4 , and R 5 in the formula (1) each has the same meaning as defined in the specification.

  提供了一种新的化合物，它抑制小鼠双分子分钟2（Mdm2）蛋白与p53蛋白之间的相互作用，并展现出抗肿瘤活性。本发明提供了一种咪唑噻唑衍生物，其表示为以下公式（1），具有各种取代基，可抑制Mdm2蛋白与p53蛋白之间的相互作用并展现出抗肿瘤活性：其中，公式（1）中的R1、R2、R3、R4和R5每个都具有规范中定义的相同含义。
• An efficient synthesis of substituted prolines by the selective reduction and reductive cyanation of 2-pyrrolidones
  作者：Qian Xia、Bruce Ganem

  DOI：10.1016/s0040-4039(02)00097-7

  日期：2002.2

  Substituted pyrrolidones undergo selective reduction using Cp2ZrHCl (Schwartz's reagent) to form Delta(1)-pyrrolines, which can be isolated or directly cyanated and hydrolyzed to the corresponding proline. Short syntheses of glutamic semialdehyde (ethyl ester), the marine metabolite (2S,5S)-pyrrolidine-2,5-dicarboxylic acid, and the conformationally constrained amino acid 5,5-dimethylproline, are reported. (C) 2002 Elsevier Science Ltd. All rights reserved.