水杨嗪酸 | 521-39-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 水杨嗪酸
• 英文名称: salazinic acid
• 英文别名: 1,4,10-trihydroxy-5-hydroxymethyl-8-methyl-3,7-dioxo-1,3-dihydro-7H-benzo[e]furo[3,4]benzo[1,4]dioxepine-11-carboxaldehyde；SID:24840333；1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carbaldehyde；Salazinsaeure；5,13,17-trihydroxy-12-(hydroxymethyl)-7-methyl-9,15-dioxo-2,10,16-trioxatetracyclo[9.7.0.03,8.014,18]octadeca-1(11),3(8),4,6,12,14(18)-hexaene-4-carbaldehyde
• CAS: 521-39-1
• 化学式: C₁₈H₁₂O₁₀
• 分子量: 388.287
• InChiKey: QQTKVXCQLZIJPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  160
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  水杨嗪酸 在 吡啶 作用下， 反应 50.0h， 生成 4,2'-di-O-acetyl-8',9'-di-O-ethylsalazinic acid
  参考文献：
  名称：

  ψ-esters of depsidones with a lactole ring

  摘要：

  DOI：

  10.1016/s0031-9422(00)82364-x

文献信息

• The Structure of Chalybaeizanic Acid and Quaesitic Acid, Two New Lichen Depsidones Related to Salazinic Acid
  作者：John A. Elix、Judith H. Wardlaw

  DOI：10.1071/ch99056

  日期：——

  The depsidones chalybaeizanic acid (1,4,10-trihydroxy-8-methyl-3,7-dioxo-1,3-dihydro-7 H-isobenzofuro- [4,5-b][1,4]benzodioxepin-5,11-dicarbaldehyde) (4) and quaesitic acid (11-formyl-1,4,10-trihydroxy-8- methyl-3,7-dioxo-1,3-dihydro-7 H-isobenzofuro[4,5-b][1,4]benzodioxepin-5-methyl hydrogen fumarate) (5) have been isolated from the lichens Xanthoparmelia amphixanthoides and Hypotrachyna quaesita respectively, and their structures determined by a combination of spectroscopic evidence, partial synthesis, derivatization or degradation reactions.

  去苷酮类化合物矢车菊酸 (1,4,10-trihydroxy-8-methyl-3,7-dioxo-1,3-dihydro-7 H-异苯并呋喃 [4,5-b][1,4]benzodioxepin-5,11-dicarbaldehyde) (4) 和奎氏酸（11-甲酰基-1,4,10-三羟基-8- methyl-3,7-dioxo-1,3-dihydro-7 H-异苯并呋喃并[4,5-b][1,4]苯并二氧杂环庚烷-5-甲基富马酸氢盐）（5 富马酸氢）(5) 已从地衣中分离出来 Xanthoparmelia amphixanthoides 和 和 Hypotrachyna quaesita 中分别分离出来，并通过光谱分析和化学分析相结合的方法确定了它们的结构 并通过光谱证据、部分合成、衍生化或降解反应确定了它们的结构、 衍生化或降解反应相结合的方法确定了它们的结构。
• Methods and compositions for treatment of cancer and autoimmune disease
  申请人：THE JACKSON LABORATORY

  公开号：US10207988B2

  公开（公告）日：2019-02-19

  The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.

  本文所述技术涉及诱导细胞死亡的方法。本文所述技术还涉及通过施用双链断裂修复抑制剂来治疗包括癌症和自身免疫性疾病在内的疾病。本文还描述了双链断裂修复抑制剂和筛选此类抑制剂的方法。
• Antimycobacterial activity of lichen substances
  作者：N.K. Honda、F.R. Pavan、R.G. Coelho、S.R. de Andrade Leite、A.C. Micheletti、T.I.B. Lopes、M.Y. Misutsu、A. Beatriz、R.L. Brum、C.Q.F. Leite

  DOI：10.1016/j.phymed.2009.07.018

  日期：2010.4

  We describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity. The depsides (atranorin, diffractaic and lecanoric acids), depsidones (protocetraric, salazinic, hypostictic and norstictic acids), xanthones (lichexanthone and secalonic acid), and usnic acid, as well seven orsellinic acid esters, five salazinic acid 8',9'-O-alkyl derivatives and four lichexanthone derivatives, were evaluated for their activity against Mycobacterium tuberculosis. Diffractaic acid was the most active compound (MIC value 15.6 mu g/ml, 41.6 mu M), followed by norstictic acid (MIC value 62.5 mu g/ml, 168 mu M) and usnic acid (MIC value 62.5 mu g/ml, 182 mu M). Hypostictic acid (MIC value 94.0 mu g/ml, 251 mu M) and protocetraric acid (MIC value 125 mu g/ml, 334 mu M) showed moderate inhibitory activity. The other compounds showed lower inhibitory activity on the growth of M. tuberculosis, varying from MIC values of 250 to 1370 mu M. (C) 2009 Elsevier GmbH. All rights reserved.
• Elix; Engkaninan, Australian Journal of Chemistry, 1975, vol. 28, p. 1793,1794
  作者：Elix、Engkaninan

  DOI：——

  日期：——
• Asahina; Tsukamoto, Chemische Berichte, 1934, vol. 67, p. 963,967
  作者：Asahina、Tsukamoto

  DOI：——

  日期：——