Bn(-2)[Bn(-6)]Gal3Ac4Ac(a1-4)[Bn(-6)]a-Glc1Me2Ac3Ac | 1338595-80-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bn(-2)[Bn(-6)]Gal3Ac4Ac(a1-4)[Bn(-6)]a-Glc1Me2Ac3Ac
• 英文别名: [(2R,3S,4S,5R,6R)-4-acetyloxy-6-[(2R,3R,4S,5R,6S)-4,5-diacetyloxy-6-methoxy-2-(phenylmethoxymethyl)oxan-3-yl]oxy-5-phenylmethoxy-2-(phenylmethoxymethyl)oxan-3-yl] acetate
• CAS: 1338595-80-4
• 化学式: C₄₂H₅₀O₁₅
• 分子量: 794.85
• InChiKey: GHMVOMHGGOVHHK-FKBJXRPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  57
• 可旋转键数：
  22
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  170
• 氢给体数：
  0
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  phenyl 3,4-O-isopropylidene-1-thio-β-D-galactopyranoside 在 4-二甲氨基吡啶 、 N-碘代丁二酰亚胺 、 三氟甲磺酸三甲基硅酯 、 sodium hydride 、 溶剂黄146 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 生成 Bn(-2)[Bn(-6)]Gal3Ac4Ac(a1-4)[Bn(-6)]a-Glc1Me2Ac3Ac
  参考文献：
  名称：

  Development of a highly α-selective galactopyranosyl donor based on a rational design

  摘要：

  A galactosyl donor was rationally designed based on protecting group-stereoselectivity study. This donor was prepared and tested in a series of glycosylation reaction. Excellent alpha-selectivity was observed in the test reactions. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.091

文献信息

• Development of a highly α-selective galactopyranosyl donor based on a rational design
  作者：Zhitao Li、Lisheng Zhu、Jane Kalikanda

  DOI：10.1016/j.tetlet.2011.08.091

  日期：2011.10

  A galactosyl donor was rationally designed based on protecting group-stereoselectivity study. This donor was prepared and tested in a series of glycosylation reaction. Excellent alpha-selectivity was observed in the test reactions. (C) 2011 Elsevier Ltd. All rights reserved.