1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone benzoyl hydrazone | 191219-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone benzoyl hydrazone
• 英文别名: 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone；HPMPB
• CAS: 191219-02-0
• 化学式: C₂₄H₂₀N₄O₂
• 分子量: 396.448
• InChiKey: PHYHVSUJMHFYEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.07
• 重原子数：
  30.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  79.51
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  oxovanadium(IV) sulfate 、 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone benzoyl hydrazone 以 甲醇 为溶剂， 以55%的产率得到
  参考文献：
  名称：

  Oxovanadium binuclear (IV) Schiff base complexes derived from aroyl hydrazones having subnormal magnetic moments

  摘要：

  Oxovanadium(IV) complexes of aroyl hydrazone Schiff bases, viz. salicyloyl, nicotinoyl and benzoyl hydrazones, have been synthesized and characterized by elemental analysis, spectroscopy (IR and UV-vis) methods, magnetic susceptibility, EPR measurements, molar conductance and cyclic voltammetry studies. The room-temperature magnetic moments of the complexes are in the range 0.97-1.03 B.M. and are indicative of the presence of anti-ferromagnetic exchange. A binuclear structure has been proposed for the complexes. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0277-5387(96)00487-1
• 作为产物：
  描述：

  苯甲酰肼 、 4-benzoyl-3-methyl-1-phenylpyrazol-5-one 以 甲醇 为溶剂， 以80%的产率得到1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone benzoyl hydrazone
  参考文献：
  名称：

  2-吡唑啉功能化锌配合物：可用的 N-AgI 相互作用调节其荧光特性

  摘要：

  已经设计了一种易于获得的荧光传感器 [Zn(1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone benzoyl hydrazone)(2)] (Zn-PMPB)，具有简单且构象适应性强的银阳离子受体。复合物中的中心 Zn2+ 离子和配体对与 Ag+ 离子的结合相互作用具有协同作用。Zn-PMPB 通过各种光谱技术和单晶 X 射线衍射进行了详细表征。描述了其用于检测 HEPES 缓冲（10 mM，pH 7.1）MeOH/H2O (4:6) 溶液中 Ag+ 离子的光化学特性。由于溶剂氢键失活，该荧光传感器的量子产率可以忽略不计 (0.0011)，而在与 Ag+ 络合后观察到荧光显着增加。

  DOI：

  10.1002/ejic.201001083

文献信息

• SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF RARE EARTH COMPLEXES OF 1-PHENYL-3-METHYL-4-BENZOYL-5-PYRAZOLONE BENZOYLHYDRAZONE
  作者：Zheng-Yin Yang

  DOI：10.1081/sim-120005610

  日期：2002.11.7

  1-Phenyl-3-methyl-4-benzyol-5-pyrazolone benzoylhydrazone (H2L) was prepared by condensation of 1-phenyl-3-methyl-4benzyol-5-pyrazolone with benzoylhdrazine. Six rare earth complexes of H2L have been synthesized and characterized on the basis of elemental analyses, IR, UV, H-1 NMR spectra and thermal analyses. The general formula of the complexes is Ln(HL)(3)(.)3H(2)O (where Ln(III) = La, Pr, Nd, Eu, Gd and Er). In addition, the suppression ratio (eta(r),) for O-2(-.) radicals as well as the inhibitory ratio (ill) for lipid peroxidation were determined by an UV spectral method. The results show that eta(r) and eta(1) of the complexes are around 39-51% and 20-39% respectively. For the ligand, eta(r) = 36% eta(1) = 18%.