2乙基-1H-苯并-4-羧基酸 | 84255-21-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2乙基-1H-苯并-4-羧基酸
• 中文别名: 2-乙基-1H-咪唑-4-羧酸
• 英文名称: 2-ethyl-1(3)H-imidazole-4-carboxylic acid
• 英文别名: 2-Aethyl-1(3)H-imidazol-4-carbonsaeure；2-ethyl-1H-imidazole-4-carboxylic acid；2-ethyl-1H-imidazole-5-carboxylic acid
• CAS: 84255-21-0
• 化学式: C₆H₈N₂O₂
• mdl: MFCD06203503
• 分子量: 140.142
• InChiKey: NRIUQHNTFFNDMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933290090

反应信息

• 作为产物：
  描述：

  2-ethyl-1(3)H-imidazole-4-carboxylic acid anilide 在 盐酸 作用下， 生成 2乙基-1H-苯并-4-羧基酸
  参考文献：
  名称：

  Fargher; Pyman, Journal of the Chemical Society, 1919, vol. 115, p. 1019

  摘要：

  DOI：

文献信息

• Method For Increasing Yield Of Staple Food Crop
  申请人：Kawagishi Hirokazu

  公开号：US20120122690A1

  公开（公告）日：2012-05-17

  Provided is a method of increasing a yield of a staple food crop which comprises bringing a compound represented by the following Formula (I) into contact with a plant body, excluding seeds, of a staple food crop to be cultured. The staple food crop is preferably a cereal crop, a tuber crop or the like. In the following Formula (I), R 1 and R 2 each independently represent a hydrogen atom or a monovalent substituent, or R 1 and R 2 are bound together to form an azo group; and R 3 represents a hydrogen atom or a monovalent substituent.

  提供了一种增加主食作物产量的方法，包括将以下式（I）所代表的化合物与待培育的主食作物的植物体（不包括种子）接触。主食作物最好是谷物作物、块茎作物或类似作物。在下面的式（I）中，R1和R2分别代表氢原子或一价取代基，或者R1和R2结合在一起形成偶氮基；R3代表氢原子或一价取代基。
• Selective iglur5 receptor antagonists
  申请人：——

  公开号：US20030055081A1

  公开（公告）日：2003-03-20

  The present invention provides compounds of formula (I): wherein W represents hydrogen, C 1 -C 4 alkyl, —CH 2 CO 2 H, or CO 2 H; and X represents hydrogen, C 1 -C 4 alkyl, —CH 2 CO 2 H, or CO 2 H; with the proviso that at least one of W or X must be other than hydrogen; or a prodrug or a pharmaceutically acceptable salt thereof; which are useful for treating migraine.

  本发明提供式（I）的化合物：其中W代表氢，C1-C4烷基，—CH2CO2H或CO2H；X代表氢，C1-C4烷基，—CH2CO2H或CO2H；但须满足W或X中至少有一个不是氢；或其前药或药学上可接受的盐；用于治疗偏头痛。
• sGC STIMULATORS
  申请人：IRONWOOD PHARMACEUTICALS, INC.

  公开号：US20160031903A1

  公开（公告）日：2016-02-04

  Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

  本文描述了化学式I'和I的化合物，它们可用作sGC的刺激剂，特别是NO独立，血红素依赖性的刺激剂。这些化合物还可用于治疗、预防或管理本文中披露的各种疾病。
• Aminomethyl-Biaryl Derivatives Complement Factor D inhibitors and uses thereof
  申请人：BELANGER David B.

  公开号：US20160145247A1

  公开（公告）日：2016-05-26

  The present invention provides a compound of formula (I), a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种公式（I）的化合物，一种制造本发明化合物的方法及其治疗用途。本发明还提供了一种药理活性剂的组合物和制药组合物。
• METHOD FOR REDUCING MEASUREMENT ERROR IN LATEX IMMUNOAGGLUTINATION ASSAY
  申请人：Sekisui Medical Co., Ltd.

  公开号：EP3690441A1

  公开（公告）日：2020-08-05

  The present invention is directed to a method for avoiding the influence of a blood sample on a measurement error in a latex agglutination immunoassay. The measurement error caused by a blood sample in a latex agglutination immunoassay can be reduced by a method which includes a step of bringing the sample into contact, in a liquid phase, with latex particles carrying a substance having a specific affinity for an analyte in the presence of imidazole.

  本发明涉及一种避免血样对乳胶凝集免疫测定中测量误差产生影响的方法。在乳胶凝集免疫测定中，血液样本引起的测量误差可以通过一种方法来减少，该方法包括一个步骤，即在液相中，使样本与携带对分析物有特异性亲和力的物质的乳胶颗粒接触，并有咪唑存在。