Methyl 2-[7-nitro-1-(5-phosphonooxypentanoyl)-2,3-dihydroindol-5-yl]acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Methyl 2-[7-nitro-1-(5-phosphonooxypentanoyl)-2,3-dihydroindol-5-yl]acetate
• 化学式: C₁₆H₂₁N₂O₉P
• 分子量: 416.324
• InChiKey: FEEWPLOCNLQUJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  159
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  methyl 1-acetylindoline-5-acetate 在 四氮唑 、 盐酸 、 sodium nitrate 、 硼烷 、 间氯过氧苯甲酸 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 Methyl 2-[7-nitro-1-(5-phosphonooxypentanoyl)-2,3-dihydroindol-5-yl]acetate
  参考文献：
  名称：

  Photorelease of Carboxylic Acids from 1-Acyl-7-nitroindolines in Aqueous Solution:  Rapid and Efficient Photorelease of l-Glutamate¹

  摘要：

  DOI：

  10.1021/ja990931e

文献信息

• 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS
  申请人：MEDICAL RESEARCH COUNCIL

  公开号：EP1161418A1

  公开（公告）日：2001-12-12
• [EN] 1-ACYL-7-NITROINDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHOTOCLEAVABLE PRECURSORS<br/>[FR] DERIVES DE 1-ACYL-7-NITROINDOLINE, LEUR PREPARATION ET LEUR UTILISATION COMME PRECURSEURS PHOTOLIBERABLES
  申请人：MEDICAL RES COUNCIL

  公开号：WO2000055133A1

  公开（公告）日：2000-09-21

  Photoreleasable compounds comprising a caging moiety linked to an effector moiety represented by structural formula (I) wherein R1 is hydrogen; C1-10 alkyl or substituted alkyl; O(CH2)n-Y; N(COZ)(CH2)mY; or N[(CH2)mY'[(CH2)NY]; R2 and R3 are independently selected from: hydrogen; C1-10 alkyl or substituted alkyl; or R2 and R3 together are cycloalkyl; R4 is hydrogen; C1-10 alkyl or substituted alkyl; phenyl or substituted phenyl; (CH2)nY; or (CH2)mO(CH2)nY; wherein m and n are independently between 1 and 10; Y and Y' are independently selected from hydrogen, CO2H or salts thereof or OPO32-; Z is hydrogen or C¿1-10? alkyl or substituted alkyl; and, X is an effector moiety or a group capable of being coupled or converted to an effector moiety, which are capable of releasing the effector moiety on irradiation, typically by flash irradiation with UV light. The photoreleasable compounds can therefore be used to deliver biologically active effector moieties such as neuroactive amino acids or metal chelators to sites where their activity is required.
• Photorelease of Carboxylic Acids from 1-Acyl-7-nitroindolines in Aqueous Solution:  Rapid and Efficient Photorelease of <scp>l</scp>-Glutamate¹
  作者：George Papageorgiou、David C. Ogden、Andreas Barth、John E. T. Corrie

  DOI：10.1021/ja990931e

  日期：1999.7.1