1,4,5,6-tetra-O-acetyl-sn-myoinositol | 108032-48-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4,5,6-tetra-O-acetyl-sn-myoinositol
• 英文别名: (1R,2S,3S,4R,5R,6S)-5,6-Dihydroxycyclohexane-1,2,3,4-tetrayl tetraacetate；[(1R,2S,3S,4R,5R,6S)-2,3,4-triacetyloxy-5,6-dihydroxycyclohexyl] acetate
• CAS: 108032-48-0
• 化学式: C₁₄H₂₀O₁₀
• 分子量: 348.307
• InChiKey: ZQLBHQSQMQLFBM-FDFVQJQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  1,4,5,6-tetra-O-acetyl-sn-myoinositol 、 D-mannose ethyl orthoacetate 生成 [(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-[(1S,2R,3R,4S,5R,6R)-2,3,4,5-tetraacetyloxy-6-hydroxycyclohexyl]oxyoxan-2-yl]methyl acetate
  参考文献：
  名称：

  SIBRIKOV, YU. I.;STEPANOV, A. E.;SHVETS, V. I., ZH. ORGAN. XIMII, 24,(1988) N 3, 527-535

  摘要：

  DOI：
• 作为产物：
  描述：

  1(3),4(6),5,6(4)-tetra-O-acetyl-sn-myoinositol 在 4 A molecular sieve 、 对甲苯磺酸 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 6.0h， 生成 1,4,5,6-tetra-O-acetyl-sn-myoinositol
  参考文献：
  名称：

  Sibrikov, Yu. I.; Stepanov, A. E.; Shvets, V. I., Journal of Organic Chemistry USSR (English Translation), 1986, p. 1089 - 1094

  摘要：

  DOI：

文献信息

• SIBRIKOV, YU. I.;STEPANOV, A. E.;SHVETS, V. I., ZH. ORGAN. XIMII, 25,(1990) N, S. 1043-1049
  作者：SIBRIKOV, YU. I.、STEPANOV, A. E.、SHVETS, V. I.

  DOI：——

  日期：——
• SIBRIKOV, YU. I.;STEPANOV, A. E.;SHVETS, V. I., ZH. ORGAN. XIMII, 24,(1988) N 3, 527-535
  作者：SIBRIKOV, YU. I.、STEPANOV, A. E.、SHVETS, V. I.

  DOI：——

  日期：——
• METHOD FOR OPTIMIZING POST-TRANSLATIONAL MODIFICATIONS ON RECOMBINANT PROTEINS
  申请人：Leszcyniecka, Magdalena

  公开号：EP3094639A1

  公开（公告）日：2016-11-23
• [EN] METHOD FOR OPTIMIZING POST-TRANSLATIONAL MODIFICATIONS ON RECOMBINANT PROTEINS<br/>[FR] PROCÉDÉ D'OPTIMISATION DES MODIFICATIONS POST-TRADUCTIONNELLES EFFECTUÉES SUR DES PROTÉINES RECOMBINÉES
  申请人：LESZCYNIECKA MAGDALENA

  公开号：WO2015106276A1

  公开（公告）日：2015-07-16

  A method for optimizing post-translational modifications of recombinant proteins expressed in living cells is described. More particularly, a method for modulation of host proteins in living cells that control PTMs on recombinant proteins is described that has particularly useful applications in developing manufacturing process changes or in biosimilar development. The goal of this modulation is to produce a recipe for production of a recombinant protein in the new process or in the biosimilar that will produce a targeted PTM profile in the resulting protein product. In the method one or more modulators are selected, as from a modulator library, which affect the activity of host proteins. These modulators are added to media during production such that the resulting product matches the PTMs of the reference product. The ideal set of modulators and their concentrations are identified through a unique iterative process and the combined modulators and their concentrations constitute a recipe for growth media for the production of said recombinant protein. The methodology to obtain such a recipe described herein may then be used in many applications, such as optimizing new batches of recombinant protein drugs, developing biosimilar or bio-better drugs.
• Sibrikov, Yu. I.; Stepanov, A. E.; Shvets, V. I., Journal of Organic Chemistry USSR (English Translation), 1986, p. 1089 - 1094
  作者：Sibrikov, Yu. I.、Stepanov, A. E.、Shvets, V. I.

  DOI：——

  日期：——