[(2R,3S,4R,5R,6R)-6-[[(2R,4aR,6S,7R,8R,8aS)-7-(dimethoxyphosphorylamino)-6-(4-methoxyphenoxy)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-3,4-diacetyloxy-5-(1,3-dioxoisoindol-2-yl)oxan-2-yl]methyl acetate | 955952-33-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3S,4R,5R,6R)-6-[[(2R,4aR,6S,7R,8R,8aS)-7-(dimethoxyphosphorylamino)-6-(4-methoxyphenoxy)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-3,4-diacetyloxy-5-(1,3-dioxoisoindol-2-yl)oxan-2-yl]methyl acetate
• CAS: 955952-33-7
• 化学式: C₄₂H₄₇N₂O₁₈P
• 分子量: 898.812
• InChiKey: XSYNMRQWDIHSCT-JGDZZKMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  63
• 可旋转键数：
  18
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  228
• 氢给体数：
  1
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  [(2R,3S,4R,5R,6R)-6-[[(2R,4aR,6S,7R,8R,8aS)-7-(dimethoxyphosphorylamino)-6-(4-methoxyphenoxy)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-3,4-diacetyloxy-5-(1,3-dioxoisoindol-2-yl)oxan-2-yl]methyl acetate 、 10-十一碳烯基氯酸 在 吡啶 、 4-二甲氨基吡啶 作用下， 以79%的产率得到
  参考文献：
  名称：

  N-Dimethylphosphoryl-protection in the efficient synthesis of glucosamine-containing oligosaccharides with alternate N-acyl substitutions

  摘要：

  Ready transformation of N-dimethylphosphoryl-protection into the corresponding N-acyl derivatives (in the presence of acyl chlorides and DMAP in pyridine) provided an effective approach to the synthesis of glucosamine-containing oligosaccharides with alternate N-acyl substitutions. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.108
• 作为产物：
  描述：

  (2R,4aR,6S,7R,8R,8aS)-7-(dimethoxyphosphorylamino)-6-(4-methoxyphenoxy)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-ol 、 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-O-trichloroacetimidate 在 三氟甲磺酸三甲基硅酯 、 MS 4 Angstroem 作用下， 以 二氯甲烷 为溶剂， 以64%的产率得到[(2R,3S,4R,5R,6R)-6-[[(2R,4aR,6S,7R,8R,8aS)-7-(dimethoxyphosphorylamino)-6-(4-methoxyphenoxy)-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl]oxy]-3,4-diacetyloxy-5-(1,3-dioxoisoindol-2-yl)oxan-2-yl]methyl acetate
  参考文献：
  名称：

  N-Dimethylphosphoryl-protection in the efficient synthesis of glucosamine-containing oligosaccharides with alternate N-acyl substitutions

  摘要：

  Ready transformation of N-dimethylphosphoryl-protection into the corresponding N-acyl derivatives (in the presence of acyl chlorides and DMAP in pyridine) provided an effective approach to the synthesis of glucosamine-containing oligosaccharides with alternate N-acyl substitutions. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.108