2-fluoro-5-benzyloxybenzyl alcohol | 459215-46-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-fluoro-5-benzyloxybenzyl alcohol
• 英文别名: (5-(benzyloxy)-2-fluorophenyl)methano；(5-(Benzyloxy)-2-fluorophenyl)methanol；(2-fluoro-5-phenylmethoxyphenyl)methanol
• CAS: 459215-46-4
• 化学式: C₁₄H₁₃FO₂
• 分子量: 232.254
• InChiKey: RASYDIDJRAMLQG-UHFFFAOYSA-N

物化性质

• 沸点：
  381.4±32.0 °C(Predicted)
• 密度：
  1.208±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-fluoro-5-benzyloxybenzyl alcohol 在 磺酰氯 作用下， 以 二甲基亚砜 为溶剂， 反应 4.0h， 生成 2-fluoro-5-benzyloxybenzyl cyanide
  参考文献：
  名称：

  Syntheses of 6-fluoro-meta-tyrosine and of its metabolites

  摘要：

  6-Fluoro-meta-tyrosine (1) was prepared from 2-fluoro-5-hydroxybenzaldehyde (6) based on an Erlenmeyer-Plochl azlactone strategy. Products of expected metabolism of the amino acid, including 6-fluoro-meta-tyramine (2) and its O-sulfate conjugate (3), (2-fluoro-5-hydrxoyphenyl)acetic acid (4), and 6-fluoro-meta-octopamine (5) also were prepared from 1. The use of a recently reported ultrasound-catalyzed Henry reaction facilitated the preparation of the tyramine derivative 2. The compounds synthesized are available for high performance liquid chromatography (HPLC) standards in positron emission tomography (PET) studies employing 6-[F-18]fluoro-meta-tyrosine and as reference samples for metabolic studies of the amino acid. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(02)00013-1
• 作为产物：
  描述：

  2-氟-5-羟基苯甲酸甲酯 在 lithium aluminium tetrahydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成 2-fluoro-5-benzyloxybenzyl alcohol
  参考文献：
  名称：

  질소를 포함하는 헤테로고리로 치환된 축합 피리미딘 유도체 및 그의 의약 용도

  摘要：

  这个申请涉及一种含氮杂环取代的嘧啶衍生物及其药用用途，提供了如下化合物，溶剂化合物，立体异构体或其药学上可接受的盐，以及包含它们的用于预防或治疗癌症的药学组合物：[化学式 I]。

  公开号：

  KR20210076693A

文献信息

• 질소를 포함하는 헤테로고리로 치환된 축합 피리미딘 유도체 및 그의 의약 용도
  申请人：ILDONG PHARMACEUTICAL CO., LTD. 일동제약(주)(120160670930) Corp. No ▼ 110111-6139277BRN ▼803-88-00431

  公开号：KR20210076693A

  公开（公告）日：2021-06-24

  본 출원은 질소를 포함하는 헤테로고리로 치환된 축합 피리미딘 유도체 및 그의 의약 용도에 관한 것으로서, 하기의 화학식 I로 표시되는 화합물, 용매화물, 입체 이성질체 또는 이들의 약학적으로 허용가능한 염, 및 이를 포함하는 암의 예방 또는 치료용 약제학적 조성물을 제공한다: [화학식 I] .

  这个申请涉及一种含氮杂环取代的嘧啶衍生物及其药用用途，提供了如下化合物，溶剂化合物，立体异构体或其药学上可接受的盐，以及包含它们的用于预防或治疗癌症的药学组合物：[化学式 I]。
• Syntheses of 6-fluoro-meta-tyrosine and of its metabolites
  作者：Jamie T Konkel、Junfa Fan、B Jayachandran、Kenneth L Kirk

  DOI：10.1016/s0022-1139(02)00013-1

  日期：2002.5

  6-Fluoro-meta-tyrosine (1) was prepared from 2-fluoro-5-hydroxybenzaldehyde (6) based on an Erlenmeyer-Plochl azlactone strategy. Products of expected metabolism of the amino acid, including 6-fluoro-meta-tyramine (2) and its O-sulfate conjugate (3), (2-fluoro-5-hydrxoyphenyl)acetic acid (4), and 6-fluoro-meta-octopamine (5) also were prepared from 1. The use of a recently reported ultrasound-catalyzed Henry reaction facilitated the preparation of the tyramine derivative 2. The compounds synthesized are available for high performance liquid chromatography (HPLC) standards in positron emission tomography (PET) studies employing 6-[F-18]fluoro-meta-tyrosine and as reference samples for metabolic studies of the amino acid. (C) 2002 Elsevier Science B.V. All rights reserved.