2-bromo-3-methyl-5-(4-bromo-2-methylphenyl)pyridine | 1253279-48-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-bromo-3-methyl-5-(4-bromo-2-methylphenyl)pyridine
• 英文别名: 2-bromo-5-(4-bromo-2-methylphenyl)-3-methylpyridine
• CAS: 1253279-48-9
• 化学式: C₁₃H₁₁Br₂N
• 分子量: 341.045
• InChiKey: FBDVCDGJUWUPHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  12.89
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2-bromo-3-methyl-5-(4-bromo-2-methylphenyl)pyridine 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium acetate 、 联硼酸频那醇酯 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Synthesis of new linear poly(phenylpyridyl) chains

  摘要：

  This paper describes for the first time an efficient approach of Suzuki Miyaura cross-coupling reaction leading to new mixed linear unsymmetric phenylpyridyl chains (garlands). We have studied the synthesis of new phenylpyridyl boronic species and their reactivity with a dihalogenated bipyridine to obtain four and six unit phenylpyridines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.12.074
• 作为产物：
  描述：

  6-溴-5-甲基吡啶-3-硼酸 、 5-溴-2-碘甲苯 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以30%的产率得到2-bromo-3-methyl-5-(4-bromo-2-methylphenyl)pyridine
  参考文献：
  名称：

  Synthesis of new phenylpyridyl scaffolds using the Garlanding approach

  摘要：

  One-pot reaction for the synthesis of novel phenylpyridyl derivatives and mixed quater phenylpyridyl compounds is described by using the Garlanding approach The reactions proceed with moderate to good yields in mild conditions and good reaction times This work represents a second application of the simplicity and versatility of Garlanding concept for the construction of new phenylpyridyl scaffolds. which can be considered as non-peptidic foldamer alpha-helix numerics. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2010.08.008

文献信息

• Synthesis of new phenylpyridyl scaffolds using the Garlanding approach
  作者：Anne Sophie Voisin-Chiret、Marilena Muraglia、Grégory Burzicki、Serge Perato、Filomena Corbo、Jana Sopková-de Oliveira Santos、Carlo Franchini、Sylvain Rault

  DOI：10.1016/j.tet.2010.08.008

  日期：2010.10

  One-pot reaction for the synthesis of novel phenylpyridyl derivatives and mixed quater phenylpyridyl compounds is described by using the Garlanding approach The reactions proceed with moderate to good yields in mild conditions and good reaction times This work represents a second application of the simplicity and versatility of Garlanding concept for the construction of new phenylpyridyl scaffolds. which can be considered as non-peptidic foldamer alpha-helix numerics. (C) 2010 Published by Elsevier Ltd.
• Synthesis of new linear poly(phenylpyridyl) chains
  作者：Serge Perato、Anne Sophie Voisin-Chiret、Jana Sopková-de Oliveira Santos、Rémi Legay、Hassan Oulyadi、Sylvain Rault

  DOI：10.1016/j.tet.2011.12.074

  日期：2012.2

  This paper describes for the first time an efficient approach of Suzuki Miyaura cross-coupling reaction leading to new mixed linear unsymmetric phenylpyridyl chains (garlands). We have studied the synthesis of new phenylpyridyl boronic species and their reactivity with a dihalogenated bipyridine to obtain four and six unit phenylpyridines. (C) 2011 Elsevier Ltd. All rights reserved.