methyl 11-(N-acryloylamino)undecanoate | 172102-69-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 11-(N-acryloylamino)undecanoate
• 英文别名: 11-acryloylamino-undecanoic acid methyl ester；11-Acryloylamino-undecansaeure-methylester；Methyl 11-(prop-2-enoylamino)undecanoate
• CAS: 172102-69-1
• 化学式: C₁₅H₂₇NO₃
• 分子量: 269.384
• InChiKey: HCULTCAVVATMEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 11-(N-acryloylamino)undecanoate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 以94%的产率得到11-(丙-2-烯酰氨基)十一烷酸
  参考文献：
  名称：

  Bioactive molecular sheets from self-assembly of polymerizable peptides

  摘要：

  我们已经证明，可聚合的多肽能够在浓溶液中自发组装成一种独特的片状二维结构，这种结构可以通过共价键固定下来，形成二维分子实体。这些实体已被证明在向活细胞输送货物方面非常有效，并且几乎无毒，相比之下，非聚合的纳米结构在这方面表现不佳。

  DOI：

  10.1039/b806559d
• 作为产物：
  描述：

  11-氨基十一酸 在 4-二甲氨基吡啶 、 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 生成 methyl 11-(N-acryloylamino)undecanoate
  参考文献：
  名称：

  Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 5. Telomerized Anionic Surfactants Derived from Amino Acids

  摘要：

  omega-Acryloyl anionic surfactants, whose polar heads are derived from amino acids, have been telomerized to prepare polyanions of a predetermined molecular weight. The main goal of this study was to verify whether the antiviral activity is influenced by the degree of polymerization of the polyanions. The oligomeric polyanions were evaluated for their activity against human immunodeficiency virus (HIV-1 or HIV-2) and various other RNA and DNA viruses. With regard to their anti-HIV activity, a minimum number of anionic groups was necessary to achieve an inhibitory effect. Moreover, to be active the overall conformation of the polyanion must be such that the anionic groups are located on the external site of the molecule. With some of the polyanions, a 50% inhibition concentration (IC50) as low as 1 mu g/mL, or even 0.1 mu g/mL, was noted against HIV-1 in CEM-4 and MT-4 cells, respectively. The most potent polyanions also proved active against human cytomegalovirus and herpex simplex virus at concentrations of 5-10 and 20-40 mu g/mL, respectively. No activity was observed against any of the other viruses tested (i.e., vesicular stomatitis, Sindbis, Semliki forest, parainfluenza, Junin, Tacaribe, Coxsackie, polio, reo, and vaccinia). No toxicity for the host cells was observed at concentrations up to 200 mu g/mL.

  DOI：

  10.1021/jm960493b