N-methyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine | 723341-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-methyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine
• 英文别名: N-methyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine
• CAS: 723341-65-9
• 化学式: C₁₈H₁₅N₅S
• 分子量: 333.417
• InChiKey: DBJYPFDFNHRDNQ-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,4-二甲基-2-嘧啶胺 、 6-苯基-咪唑并[2,1-b]噻唑-5-甲醛 生成 N-methyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine 、
  参考文献：
  名称：

  Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable

  摘要：

  Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.106

文献信息

• Therapeutic agents
  申请人：Luke William Arthur Richard

  公开号：US20060069109A1

  公开（公告）日：2006-03-30

  A compound of the Formula: (I) (A chemical formula should be inserted here—please see paper copy enclosed herewith) Formula: (I); for use as a Tie2 receptor tyrosine kinase inhibitor in a warm-blooded animal such as man.

  化合物的化学式为：（I）（化学式应插入此处-请参阅随附的纸质副本）化学式：（I）； 用于作为Tie2受体酪氨酸激酶抑制剂在温血动物（如人）中使用。
• ANTI-ANGIOGENETIC THERAPEUTIC AGENTS
  申请人：AstraZeneca AB

  公开号：EP1575963B1

  公开（公告）日：2008-05-07
• Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
  作者：David Buttar、Mike Edge、Steve C. Emery、Martina Fitzek、Cheryl Forder、Alison Griffen、Barry Hayter、Chris F. Hayward、Philip J. Hopcroft、Richard W.A. Luke、Ken Page、John Stawpert、Andy Wright

  DOI：10.1016/j.bmcl.2008.06.106

  日期：2008.8

  Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.