6-Fluoro-1-hydroxy-4-methoxy-2-[1-(methoxymethoxy)ethyl]anthracene-9,10-dione | 200861-07-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 6-Fluoro-1-hydroxy-4-methoxy-2-[1-(methoxymethoxy)ethyl]anthracene-9,10-dione
• CAS: 200861-07-0
• 化学式: C₁₉H₁₇FO₆
• 分子量: 360.339
• InChiKey: RXXXAKGCAWKEPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-Fluoro-1-hydroxy-4-methoxy-2-[1-(methoxymethoxy)ethyl]anthracene-9,10-dione 在 4-二甲氨基吡啶 、 三氯化硼 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 97.33h， 生成 4-(4-Methoxy-benzyloxycarbonylamino)-cyclohexanecarboxylic acid 1-(6-fluoro-1,4-dihydroxy-9,10-dioxo-9,10-dihydro-anthracen-2-yl)-ethyl ester
  参考文献：
  名称：

  The synthesis of anthraquinone derivatives as potential anticancer agents

  摘要：

  The simple anthracycline analogues 3a-c were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation of p-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)10195-8
• 作为产物：
  描述：

  6-氟-3-氧代-1H-2-苯并呋喃-1-腈 、 1-(4,4-dimethoxycyclohexa-2,5-dienon-2-yl)-1-methoxymethyloxyethane 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以70%的产率得到6-Fluoro-1-hydroxy-4-methoxy-2-[1-(methoxymethoxy)ethyl]anthracene-9,10-dione
  参考文献：
  名称：

  The synthesis of anthraquinone derivatives as potential anticancer agents

  摘要：

  The simple anthracycline analogues 3a-c were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation of p-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)10195-8

文献信息

• The synthesis of anthraquinone derivatives as potential anticancer agents
  作者：Ping Ge、Richard A. Russell

  DOI：10.1016/s0040-4020(97)10195-8

  日期：1997.12

  The simple anthracycline analogues 3a-c were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation of p-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds. (C) 1997 Elsevier Science Ltd.