Methyl 2-(3-oxopropylsulfanyl)acetate | 128375-90-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 2-(3-oxopropylsulfanyl)acetate
• CAS: 128375-90-6
• 化学式: C₆H₁₀O₃S
• 分子量: 162.21
• InChiKey: SLXAHSKBHDGPKP-UHFFFAOYSA-N

物化性质

• 沸点：
  236.5±25.0 °C(Predicted)
• 密度：
  1.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  prop-2-enyl 2-thiabicyclo<2.2.1>hept-5-ene-endo/exo-3-carboxylate 在 silica gel 作用下， 反应 2.25h， 生成 Methyl 2-(3-oxopropylsulfanyl)acetate
  参考文献：
  名称：

  Choi, Samuel S.-M.; Kirby, Gordon W.; Mahajan, Mohinder P., Journal of the Chemical Society. Perkin transactions I, 1992, # 2, p. 191 - 198

  摘要：

  DOI：

文献信息

• Zeolite mediated michael addition of 1,3-dicarbonyl compounds and thiols
  作者：R. Sreekumar、P. Rugmini、Raghavakaimal Padmakumar

  DOI：10.1016/s0040-4039(97)01494-9

  日期：1997.9

  Zeolites, an environmentally attractive solid catalyst, proves to be an efficient catalyst for Michael addition of several 1, 3-dicarbonyl compounds and thiols as donors with methyl vinyl ketone, acrolein and methyl acrylate as acceptors without any solvent are described.

  沸石，一种对环境有吸引力的固体催化剂，被证明是一种有效的催化剂，用于迈克尔加成几种1，3-二羰基化合物和硫醇作为供体，其中描述了甲基乙烯基酮，丙烯醛和丙烯酸甲酯作为受体，没有任何溶剂。
• Thialactones formed by intramolecular ‘ene’ reactions of thioaldehydes
  作者：Samuel S.-M. Choi、Gordon W. Kirby、Mohinder P. Mahajan

  DOI：10.1039/c39900000138

  日期：——

  ω-Vinylalkyl esters (3) of thioxoacetic acid, generated by retro-Diels–Alder cleavage of their cyclopentadiene cycloadducts (2), underwent Type III intramolecular ‘ene’ reactions during flash vacuum pyrolysis at 500 °C to give 3-thialactones having 6- to 11-membered rings.

  ω-乙烯基烷基酯（3 thioxoacetic酸的），可以通过环戊二烯cycloadducts（的逆狄尔斯-阿尔德切割产生2），闪速真空热解过程中经历了III型分子内“烯”反应，在500℃，得到具有6 3- thialactones -至11元环。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• Surface-mediated solid phase reaction: Dramatic improvement of Michael reaction on the surface of alumina
  作者：Brindaban C. Ranu、Sanjay Bhar

  DOI：10.1016/s0040-4020(01)90794-x

  日期：1992.1

  The Michael reaction of several 1,3-dicarbonyl compounds, nitroalkanes, and thiols as donors with methyl vinyl ketone, acrolein, methyl acrylate, methyl methacrylate, and mesityl oxide as acceptors on the surface of alumina without any solvent proceed very effeciently and furnish high yield of adducts.
• CHOI, SAMUEL S. M.;, KIRBY GORDON W.;MAHAJAN, MOHINDER P., J. CHEM. SOC. CHEM. COMMUN.,(1990) N, C. 138-140
  作者：CHOI, SAMUEL S. M.、, KIRBY GORDON W.、MAHAJAN, MOHINDER P.

  DOI：——

  日期：——