methyl 2-amino-2-deoxy-α-D-mannopyranoside hydrochloride | 3867-93-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-amino-2-deoxy-α-D-mannopyranoside hydrochloride
• 英文别名: (2R,3S,4R,5S,6S)-5-amino-2-(hydroxymethyl)-6-methoxyoxane-3,4-diol;hydrochloride
• CAS: 3867-93-4；13374-29-3；68405-78-7；76101-73-0；85141-83-9；134227-31-9
• 化学式: C₇H₁₅NO₅*ClH
• 分子量: 229.661
• InChiKey: ZHBLANRNRXZVRP-MFEJMGMWSA-N

物化性质

• 熔点：
  185° - 187°C
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -2.18
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  105
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲醇 、 2-amino-D-2-deoxy-mannose 在 盐酸 作用下， 反应 12.0h， 生成 methyl 2-amino-2-deoxy-α-D-mannopyranoside hydrochloride
  参考文献：
  名称：

  含2-氨基-2-脱氧-d-甘露糖的铜（II）配合物及其衍生物的稳定性和结构

  摘要：

  摘要电位和光谱研究表明，2-氨基-2-脱氧-d-甘露糖（ManN），其甲基α-糖吡喃糖苷和甲基2-氨基-2-脱氧-α，β-d-吡喃半乳糖苷是用于制备高品质螯合剂的良好螯合剂。铜离子。具有甘露聚糖化合物的配合物的稳定常数高于2-氨基-2-脱氧-d-半乳糖（GalN）和2-氨基-2-脱氧-d-葡萄糖（GlcN）的稳定常数。主要结合位点是氨基，甘露聚糖化合物中最有效的次要位点是HO-3。GalN，GlcN，ManN及其甲基糖吡喃糖苷的配位能力的比较表明，各种羟基可参与金属离子的结合。还列出了Ni（II）和Co（II）与ManN配合物的稳定性常数。

  DOI：

  10.1016/0008-6215(90)84134-g

文献信息

• METHOD FOR EVALUATING SPECIFIC INCORPORATION OF D-GLUCOSE INTO CELLS
  申请人：Yamada Katsuya

  公开号：US20110189708A1

  公开（公告）日：2011-08-04

  An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.

  本发明的目的是提供一种准确评估D-葡萄糖进入细胞的特定结合的方法。本发明的手段是通过将具有荧光色团的D-葡萄糖衍生物和具有荧光色团的L-葡萄糖衍生物与同一细胞系的不同细胞接触，分别比较具有荧光色团的D-葡萄糖衍生物和特定结合到细胞中的荧光强度与具有荧光色团的L-葡萄糖衍生物的荧光强度，并通过两种荧光强度的差异来评估D-葡萄糖相对于L-葡萄糖的特定结合到细胞中的情况。
• L-glucose derivatives having fluorescent chromophore
  申请人：HIROSAKI UNIVERSITY

  公开号：US20150212094A1

  公开（公告）日：2015-07-30

  An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.

  本发明的目的是提供一种准确评估D-葡萄糖特异性进入细胞的方法。本发明的手段是通过将具有荧光色团的D-葡萄糖衍生物与分别具有荧光色团的L-葡萄糖衍生物接触同一细胞系的不同细胞，比较D-葡萄糖衍生物和L-葡萄糖衍生物发出的荧光，通过两种荧光强度之间的差异来评估D-葡萄糖相对于L-葡萄糖特异性地进入细胞。
• US4057684A
  申请人：——

  公开号：US4057684A

  公开（公告）日：1977-11-08
• US8986656B2
  申请人：——

  公开号：US8986656B2

  公开（公告）日：2015-03-24
• US9958450B2
  申请人：——

  公开号：US9958450B2

  公开（公告）日：2018-05-01