1-((Benzyloxycarbonyl)amino)-2-hydroxyethyl phenyl ketone | 152528-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-((Benzyloxycarbonyl)amino)-2-hydroxyethyl phenyl ketone
• 英文别名: benzyl N-(3-hydroxy-1-oxo-1-phenylpropan-2-yl)carbamate
• CAS: 152528-96-6
• 化学式: C₁₇H₁₇NO₄
• 分子量: 299.326
• InChiKey: XOPDFKYDQVMJTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-((Benzyloxycarbonyl)amino)-2-hydroxyethyl phenyl ketone 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 7.0h， 生成 1-((Benzyloxycarbonyl)amino)-2-hydroxyethyl phenyl ketone oxime
  参考文献：
  名称：

  Synthesis of amino acids and related compounds. 42. A novel transformation of imidazolines into 2,4,6-trisubstituted pyrimidine derivatives

  摘要：

  2,5-Diaryl-4-(chloromethyl)imidazoline derivatives 5a-g, obtained from N-acyl-alpha-amino ketone derivatives 1, were rearranged with sodium hydride in dimethylformamide. Spontaneous air oxidation led to 2,4-di- and 2,4,6-triarylpyrimidine derivatives 6a-g in good yields.

  DOI：

  10.1021/jo00075a032
• 作为产物：
  描述：

  聚合甲醛 、 (N-(Benzyloxycarbonyl)amino)-methyl phenyl ketone 在 potassium carbonate 作用下， 以 异丙醇 为溶剂， 以73.4%的产率得到1-((Benzyloxycarbonyl)amino)-2-hydroxyethyl phenyl ketone
  参考文献：
  名称：

  Synthesis of amino acids and related compounds. 42. A novel transformation of imidazolines into 2,4,6-trisubstituted pyrimidine derivatives

  摘要：

  2,5-Diaryl-4-(chloromethyl)imidazoline derivatives 5a-g, obtained from N-acyl-alpha-amino ketone derivatives 1, were rearranged with sodium hydride in dimethylformamide. Spontaneous air oxidation led to 2,4-di- and 2,4,6-triarylpyrimidine derivatives 6a-g in good yields.

  DOI：

  10.1021/jo00075a032

文献信息

• Synthesis of amino acids and related compounds. 42. A novel transformation of imidazolines into 2,4,6-trisubstituted pyrimidine derivatives
  作者：Masahiko Seki、Hitoshi Kubota、Kazuo Matsumoto、Akio Kinumaki、Tadamasa Date、Kimio Okamura

  DOI：10.1021/jo00075a032

  日期：1993.11

  2,5-Diaryl-4-(chloromethyl)imidazoline derivatives 5a-g, obtained from N-acyl-alpha-amino ketone derivatives 1, were rearranged with sodium hydride in dimethylformamide. Spontaneous air oxidation led to 2,4-di- and 2,4,6-triarylpyrimidine derivatives 6a-g in good yields.