N^α-tert-butyloxycarbonyl-N^ε-benzyloxycarbonyllysyl-alanine | 31310-97-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^α-tert-butyloxycarbonyl-N^ε-benzyloxycarbonyllysyl-alanine
• 英文别名: tBoc-Lys(Cbz)-Ala-OH；(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoyl]amino]propanoic acid
• CAS: 31310-97-1
• 化学式: C₂₂H₃₃N₃O₇
• 分子量: 451.52
• InChiKey: YABCBKFIOCZIPV-RDJZCZTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N^α-tert-butyloxycarbonyl-N^ε-benzyloxycarbonyllysyl-alanine 在 钯 氢气 作用下， 生成 tert-butoxycarbonyl-L-lysyl-L-alanine
  参考文献：
  名称：

  Skalaban,T.D. et al., Journal of Organic Chemistry USSR (English Translation), 1971, vol. 7, p. 47 - 50

  摘要：

  DOI：
• 作为产物：
  描述：

  BOC-(Z)Lys-Ala-OMe 在 sodium hydroxide 作用下， 以 异丙醇 为溶剂， 反应 2.0h， 以66%的产率得到N^α-tert-butyloxycarbonyl-N^ε-benzyloxycarbonyllysyl-alanine
  参考文献：
  名称：

  Pirkova, Jana; Churkina, Svetlana; Gut, Vladimir, Collection of Czechoslovak Chemical Communications, 1988, vol. 53, # 1, p. 145 - 156

  摘要：

  DOI：

文献信息

• Polycationic oligomers
  申请人：Emory University

  公开号：US06153596A1

  公开（公告）日：2000-11-28

  The present invention relates to improved methods for introducing nucleic acid into cells by first complexing the nucleic acid with a selected polycationic oligomer which neutralizes the negative charge of the nucleic acid, and then contacting the cell with the complex facilitating uptake of the nucleic acid into the cells as a complex with the oligomer. The methods are preferably applied to introduction of nucleic acid into eukaryotic cells, and more preferably into human cells. The invention also relates to methods of introducing antisense and triplex-forming oligonucleotides into prostate cancer cells to inhibit expression of proteins associated with (or that promote) malignancy and to inhibit cell growth or proliferation. More particularly, the invention relates to a method for inhibiting the expression of the HER-2/NEU protein in prostate cancer cells and to a method for inhibiting prostate cancer cell growth or proliferation.

  本发明涉及改进的方法，通过首先将核酸与选择的多阳离子寡聚体结合，中和核酸的负电荷，然后将复合物与细胞接触，促进核酸与寡聚体复合物进入细胞。该方法首选应用于将核酸引入真核细胞，更首选是人类细胞。本发明还涉及将反义和三股形成寡核苷酸引入前列腺癌细胞的方法，以抑制与（或促进）恶性肿瘤相关的蛋白质的表达，并抑制细胞生长或增殖。更具体地，本发明涉及一种抑制前列腺癌细胞中HER-2/NEU蛋白表达的方法，以及一种抑制前列腺癌细胞生长或增殖的方法。
• Slotin,L.A. et al., Canadian Journal of Chemistry, 1977, vol. 55, p. 4257 - 4266
  作者：Slotin,L.A. et al.

  DOI：——

  日期：——
• Design of high-affinity peptide conjugates with optimized fluorescence quantum yield as markers for small peptide transporter PEPT1 (SLC15A1)
  作者：Praveen M. Bahadduri、Abhijit Ray、Akash Khandelwal、Peter W. Swaan

  DOI：10.1016/j.bmcl.2008.03.044

  日期：2008.4

  We employed a computational approach to design and synthesize a series of. fluorescently labeled hPEPT1 substrates. Five Alexa Fluor-350 (TM)-labeled peptides were assessed for their in vitro inhibitory activity in hPEPT1-transfected CHO cells. At least four labeled peptides show potent inhibitory activity toward hPEPT1-mediated uptake of [H-3]-GlySar and three compounds displayed a significant cellular uptake specifically mediated by hPEPT1. (c) 2008 Elsevier Ltd. All rights reserved.