(2S,3S,4R,5S,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-3,4,5-tris((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde | 1225326-95-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4R,5S,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-3,4,5-tris((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde
• CAS: 1225326-95-3
• 化学式: C₄₄H₄₅ClO₉
• 分子量: 753.289
• InChiKey: MVKGOOROWZKGKX-PKDXBGGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.36
• 重原子数：
  54.0
• 可旋转键数：
  17.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  90.91
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 (2S,3S,4R,5S,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-3,4,5-tris((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 异丙醇 为溶剂， 以48%的产率得到((3S,4R,5S,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-3,4,5-tris((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-2,2-diyl)dimethanol
  参考文献：
  名称：

  Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

  摘要：

  Several syntheses of C-5-spirocycle-containing C-glycosides are discussed. A multigram-scale synthesis capitalizing on a one-pot aldol-Cannizzaro sequence is described. Spiro oxetane formation using an unprotected penta-ol C-glycoside as substrate is also exemplified. Functional assessment of these compounds for potency and selectivity was evaluated at human SGLT2 and SGLT1. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.024
• 作为产物：
  描述：

  ((2R,3R,4R,5S,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-3,4,5-tris((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-2-yl)methanol 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到(2S,3S,4R,5S,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-3,4,5-tris((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde
  参考文献：
  名称：

  Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

  摘要：

  Several syntheses of C-5-spirocycle-containing C-glycosides are discussed. A multigram-scale synthesis capitalizing on a one-pot aldol-Cannizzaro sequence is described. Spiro oxetane formation using an unprotected penta-ol C-glycoside as substrate is also exemplified. Functional assessment of these compounds for potency and selectivity was evaluated at human SGLT2 and SGLT1. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.024