methyl 2,3-dichloro-3-oxopropanoate | 60180-62-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2,3-dichloro-3-oxopropanoate
• CAS: 60180-62-3
• 化学式: C₄H₄Cl₂O₃
• 分子量: 170.98
• InChiKey: VGLAESBBSQCKBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2,3-dichloro-3-oxopropanoate 在 三乙胺 作用下， 以 正己烷 为溶剂， 生成 (carbomethoxy)chloroketene
  参考文献：
  名称：

  A short, economical, and stereoselective route to prostaglandins by vicinal alkylation of cyclopentadiene

  摘要：

  DOI：

  10.1021/ja00405a070
• 作为产物：
  描述：

  甲基丙二酸氢 在 磺酰氯 、 五氯化磷 作用下， 生成 methyl 2,3-dichloro-3-oxopropanoate
  参考文献：
  名称：

  A short, economical, and stereoselective route to prostaglandins by vicinal alkylation of cyclopentadiene

  摘要：

  DOI：

  10.1021/ja00405a070

文献信息

• TRICYCLIC COMPOUND
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP1939205A1

  公开（公告）日：2008-07-02

  The present invention relates to tricyclic compounds each represented by the following formula (I): (wherein, R1, R2, R2', R3, R4, X, Y and Z have the same meanings as defined in the specification); and a drug containing the compound. Since the compounds according to the present invention exhibit an excellent squalene synthetase inhibitory effect and cholesterol synthesis inhibitory effect so that they are useful as a drug such as preventive and/or remedy for diseases in mammals including humans such as hyperlipemia, e.g., hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia and/or arteriosclerosis.

  本发明涉及一种三环化合物，每种化合物由以下式（I）表示：（其中，R1、R2、R2'、R3、R4、X、Y和Z的含义与规范中定义的含义相同）；以及含有该化合物的药物。由于根据本发明的化合物表现出优异的角鲨烯合酶抑制作用和胆固醇合成抑制作用，因此它们可用作哺乳动物（包括人类）的疾病预防和/或治疗药物，例如高脂血症，如高胆固醇血症、高甘油三酯血症、低高密度脂蛋白胆固醇血症和/或动脉粥样硬化。
• MESOIONIC IMIDAZOPYRIDINES AS INSECTICIDES
  申请人：BAYER AKTIENGESELLSCHAFT

  公开号：US20200146292A1

  公开（公告）日：2020-05-14

  Provided are compounds of the formula (I) which are suitable for controlling animal pests, including arthropods and in particular insects, arachnids and nematodes, and in which the structural elements R 1 , p, T and G have the meanings given in the description, as are processes for their preparation and their use as insecticides.

  提供了符合化合物的公式(I)，适用于控制动物害虫，包括节肢动物，特别是昆虫、蛛形动物和线虫，其中结构元素R1、p、T和G的含义如描述所示，以及它们的制备过程和用作杀虫剂的用途。
• Oxidative free-radical cyclization of allylic α-chloromalonates. Synthesis of (±)-avenaciolide.
  作者：Barry B. Snider、Bridget A. McCarthy

  DOI：10.1016/s0040-4020(01)80213-1

  日期：——

  Oxidative free-radical cyclization of α-chloromalonate 9 with Mn(OAc)3·2H2O and Cu(Oac)2·H2O in acetic acid at 75 °C provides 82% of lactones 10a and 10b. Hydroboration of 10 followed by oxidation affords acids 12, which are converted to avenaciolide precursor 15 in 32% overall yield from 9 by decarboxylation and cyclization.

  在75°C的乙酸中，用Mn（OAc）3 ·2H 2 O和Cu（Oac）2 ·H 2 O在乙酸中对α-氯丙二酸酯9进行氧化自由基环化，得到82％的内酯10a和10b。10的氢硼化然后氧化得到酸12，通过脱羧和环化，酸从9转化为阿那维利特前体15，总产率为32％。
• Mesoionic imidazole derivatives as insecticides
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20180282323A1

  公开（公告）日：2018-10-04

  What are demonstrated are compounds of the formula (I) which are suitable for controlling animal pests, including arthropods and especially insects, arachnids and nematodes, and in which the structural elements Q 1 , Q 2 , W, T, Y, G and U have the definitions given in the description, as are processes for preparation thereof and the use thereof as insecticides.

  展示的是公式（I）的化合物，适用于控制动物害虫，包括节肢动物，尤其是昆虫，蜘蛛和线虫，其中结构元素Q1，Q2，W，T，Y，G和U的定义如描述中所述，并且包括制备过程和用作杀虫剂的用途。
• TRICYCLIC COMPOUNDS
  申请人：Sugita Kazuyuki

  公开号：US20090181942A1

  公开（公告）日：2009-07-16

  The present invention relates to tricyclic compounds each represented by the following formula (I): (wherein, R 1 , R 2 , R 2′ , R 3 , R 4 , X, Y and Z have the same meanings as defined in the specification); and a drug containing the compound. Since the compounds according to the present invention exhibit an excellent squalene synthetase inhibitory effect and cholesterol synthesis inhibitory effect so that they are useful as a drug such as preventive and/or remedy for diseases in mammals including humans such as hyperlipemia, e.g., hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia and/or arteriosclerosis.

  本发明涉及由以下公式（I）表示的三环化合物（其中，R1，R2，R2'，R3，R4，X，Y和Z的含义如说明书所定义）；以及含有该化合物的药物。由于本发明的化合物表现出优异的角鲨烷合酶抑制作用和胆固醇合成抑制作用，因此它们可用作哺乳动物（包括人类）疾病的预防和/或治疗药物，例如高脂血症、例如高胆固醇血症、高三酰甘油血症和低高密度脂蛋白胆固醇血症和/或动脉硬化。