| 887326-69-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 887326-69-4
• 化学式: C₄₇H₇₁NO₁₂Si₂
• 分子量: 898.251
• InChiKey: VJLYYJUASVDWQZ-SPNFSFDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.02
• 重原子数：
  62.0
• 可旋转键数：
  19.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  146.31
• 氢给体数：
  1.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  在 2-硝基苯磺酰肼 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以97%的产率得到[(2S,3R,6R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-[(2S,3R,6S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-[4-[(2R)-3-methoxy-3-oxo-2-(phenylmethoxycarbonylamino)propyl]phenoxy]oxan-3-yl]oxyoxan-3-yl] 3-methylbutanoate
  参考文献：
  名称：

  Synthetic Studies toward Mannopeptimycin-E:  Synthesis of the O-Linked Tyrosine 1,4-α,α-manno,manno-Pyranosyl Pyranoside

  摘要：

  The enantioselective synthesis of the C-4' acylated 1,4-alpha,alpha-manno,manno-disaccharide fragment of mannopeptimycin-E has been achieved in seven steps from D-tyrosine. The route relies upon diastereoselective palladium-catalyzed glycosylation, diastereoselective reduction, and diastereoselective bis-dihydroxylation. The efficiency of the synthesis is demonstrated by the high overall yield (37%) and the preparation of various analogues.

  DOI：

  10.1021/ol060254a
• 作为产物：
  描述：

  Z-D-酪氨酸甲基酯 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 三苯基膦 sodium tetrahydroborate 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthetic Studies toward Mannopeptimycin-E:  Synthesis of the O-Linked Tyrosine 1,4-α,α-manno,manno-Pyranosyl Pyranoside

  摘要：

  The enantioselective synthesis of the C-4' acylated 1,4-alpha,alpha-manno,manno-disaccharide fragment of mannopeptimycin-E has been achieved in seven steps from D-tyrosine. The route relies upon diastereoselective palladium-catalyzed glycosylation, diastereoselective reduction, and diastereoselective bis-dihydroxylation. The efficiency of the synthesis is demonstrated by the high overall yield (37%) and the preparation of various analogues.

  DOI：

  10.1021/ol060254a