(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]pent-4-en-1-ol | 890532-87-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]pent-4-en-1-ol
• CAS: 890532-87-3
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.251
• InChiKey: XJSFRPDSKRKHNP-IUCAKERBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]pent-4-en-1-ol 在 Grubbs catalyst first generation 4-二甲氨基吡啶 、 TEA 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 生成
  参考文献：
  名称：

  Stereoselective synthesis of bis-hydroxy-tetrahydrofurans using cross metathesis

  摘要：

  A short asymmetric approach for the synthesis of bis-tetrahydrofuran units of various annonaceous acetogenins is described. The key steps of the synthesis are self-cross metathesis and Sharpless asymmetric dihydroxylation. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.080
• 作为产物：
  描述：

  (2S,3S)-3,4-epoxy-1,2-di-O-isopropylidenebutane-1,2-diol 、 烯丙基溴化镁 在 copper(l) iodide 作用下， 以 乙醚 为溶剂， 反应 12.0h， 以85%的产率得到(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]pent-4-en-1-ol
  参考文献：
  名称：

  Stereoselective synthesis of bis-hydroxy-tetrahydrofurans using cross metathesis

  摘要：

  A short asymmetric approach for the synthesis of bis-tetrahydrofuran units of various annonaceous acetogenins is described. The key steps of the synthesis are self-cross metathesis and Sharpless asymmetric dihydroxylation. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.080

文献信息

• Stereoselective synthesis of bis-hydroxy-tetrahydrofurans using cross metathesis
  作者：Errabelli Ramu、G. Bhaskar、B. Venkateswara Rao、G.S. Ramanjaneyulu

  DOI：10.1016/j.tetlet.2006.03.080

  日期：2006.5

  A short asymmetric approach for the synthesis of bis-tetrahydrofuran units of various annonaceous acetogenins is described. The key steps of the synthesis are self-cross metathesis and Sharpless asymmetric dihydroxylation. (c) 2006 Elsevier Ltd. All rights reserved.