(6-甲氧基-1,3-苯并二氧代l-5-基)胺 | 69151-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 中文名称: (6-甲氧基-1,3-苯并二氧代l-5-基)胺
• 中文别名: (试剂)(6-METHOXY-1,3-BENZODIOXOL-5-YL)AMINE
• 英文名称: 1,2-methylenedioxy-4-methoxy-5-aminobenzene
• 英文别名: 1-amino-2-methoxy-4,5-methylenedioxybenzene；1-amino-6-methoxy-3,4-methylenedioxybenzene；3,4-methylenedioxy-6-methoxy-1-aminobenzene；2-methoxy-4,5-methylenedioxyaniline；6-methoxy-benzo[1,3]dioxol-5-ylamine；6-Methoxy-benzo[1,3]dioxol-5-ylamin；(6-Methoxy-1,3-benzodioxol-5-yl)amine；6-methoxy-1,3-benzodioxol-5-amine
• CAS: 69151-32-2
• 化学式: C₈H₉NO₃
• mdl: MFCD08445370
• 分子量: 167.164
• InChiKey: BKYQHRSVSLQLLQ-UHFFFAOYSA-N

物化性质

• 熔点：
  56 °C
• 沸点：
  289.1±40.0 °C(Predicted)
• 密度：
  1.317±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2932999099
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : (6-Methoxy-1,3-benzodioxol-5-yl)amine
CAS-No. : 69151-32-2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
The product does not need to be labelled in accordance with EC directives or respective national laws.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C8H9NO3
Molecular Weight : 167,16 g/mol

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Section 4. FIRST AID MEASURES
Description of first aid measures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing vapors, mist or gas.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Choose body protection in relation to its type, to the concentration and amount of dangerous
substances, and to the specific work-place., The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- log Pow: 1,366
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

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Section 16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

反应信息

• 作为反应物：
  描述：

  (6-甲氧基-1,3-苯并二氧代l-5-基)胺 在 Brettphos palladacycle 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 15.0h， 生成
  参考文献：
  名称：

  一种N-卤代乙酰基二苯胺衍生物及其制备方法和医药用途

  摘要：

  本发明公开了一种N‑卤代乙酰基二苯胺衍生物及其制备方法和医药用途，该N‑卤代乙酰基二苯胺衍生物的结构如式I所示。本发明N‑卤代乙酰基二苯胺衍生物对正常细胞具有较低的抑制作用，提高了GPX4共价抑制剂的选择性，且本发明N‑卤代乙酰基二苯胺衍生物在细胞水平上可以抑制三阴性乳腺癌肿瘤细胞的增殖，在动物水平上可以抑制裸鼠移植瘤的生长，改善GPX4抑制剂体内抗肿瘤作用，可用于治疗三阴性乳腺癌。

  公开号：

  CN115960073A
• 作为产物：
  描述：

  6-methoxy-benzo[1,3]dioxole-5-carboxylic acid 在 palladium on activated charcoal 、 乙醇 、 硝酸 、 溶剂黄146 作用下， 生成 (6-甲氧基-1,3-苯并二氧代l-5-基)胺
  参考文献：
  名称：

  Simonitsch et al., Monatshefte fur Chemie, 1957, vol. 88, p. 541,558

  摘要：

  DOI：

文献信息

• Dyeing compositions for keratinous fibres containing paraphenylenediamine derivatives with pyrrolidinyl group
  申请人：——

  公开号：US20030093866A1

  公开（公告）日：2003-05-22

  The invention concerns novel dyeing compositions for keratinous fibers comprising at least a paraphenylenediamine derivative with pyrrolidinyl group as oxidation base, a dyeing method and a dyeing kit using said composition.

  该发明涉及一种用于角蛋白纤维的新型染色组合物，包括至少一种带有吡咯啉基团的对苯二胺衍生物作为氧化剂基础，一种染色方法和使用该组合物的染色套件。
• Oxidation dyeing composition for keratinous fibres on amphiphilic polymers of at least an ethylenically unsaturated monomer with sulphonic group and comprising a hydrophobic part
  申请人：Kravtchenko Sylvain

  公开号：US20050086745A1

  公开（公告）日：2005-04-28

  The invention concerns an oxidation dyeing composition for keratinous fibres, in particular for human keratinous fibres and more particularly hair, comprising, in a medium suited for dyeing, at least an oxidation dyeing agent, and also at least an amphiphilic polymer including at least an ethylenically unsaturated monomer with a sulphonic group, in free form or partly or completely neutralised and further at least a hydrophobic part. The invention also concerns dyeing methods and devices using said composition.

  本发明涉及一种用于角蛋白纤维的氧化染色组合物，特别是用于人类角蛋白纤维，更特别是用于头发，所述组合物包括至少一种适用于染色的介质中的氧化染色剂，以及至少一种含有至少一种具有磺酸基的乙烯基不饱和单体的两亲性聚合物，其在自由形式或部分或完全中和的形式下进一步至少具有一个疏水部分。本发明还涉及使用所述组合物的染色方法和装置。
• Compositions for dyeing keratin fibers, containing cationic indolizine derivatives, and dyeing process
  申请人：——

  公开号：US20010044974A1

  公开（公告）日：2001-11-29

  Compositions for the oxidation dyeing of keratin fibres, containing at least one oxidation base and at least one coupler chosen from indolizine derivative comprising at least one cationic group Z, Z being chosen from quaternized aliphatic chains, aliphatic chains comprising at least one quaternized saturated ring, and aliphatic chains comprising at least one quaternized unsaturated ring. Methods of using these cationic indolizine derivatives as couplers for the oxidation dyeing of keratin fibres, in combination with at least one oxidation base, and to dyeing processes using them. Some of these cationic indolizine derivatives are novel.

  含有至少一个氧化碱和至少一个偶合剂的角蛋白纤维氧化染料组合物，所述偶合剂选自包含至少一个阳离子基团Z的吲哚啉衍生物，其中Z选自季铵化的脂肪链，包含至少一个季铵化饱和环的脂肪链，以及包含至少一个季铵化不饱和环的脂肪链。使用这些阳离子吲哚啉衍生物作为角蛋白纤维氧化染料的偶合剂的方法，与至少一个氧化碱结合使用，并使用它们进行染色过程。其中一些阳离子吲哚啉衍生物是新颖的。
• Composition comprising at least one conductive polymer and at least one oxidation dye, and process for the use thereof
  申请人：Rollat-Corvol Isabelle

  公开号：US20050060816A1

  公开（公告）日：2005-03-24

  The disclosure relates to compositions comprising, in a cosmetically acceptable medium, (a) at least one oxidation dye and (b) at least one conductive polymer. The disclosure also relates to ready-to-use compositions comprising the abovementioned compositions, processes using such a ready-to-use composition, and methods of using the compositions for giving keratin fibers an optical effect.

  本公开涉及一种化妆品可接受介质中包含（a）至少一种氧化染料和（b）至少一种导电聚合物的组合物。本公开还涉及包含上述组合物的即用型组合物、使用此即用型组合物的过程以及使用该组合物为角蛋白纤维提供光学效应的方法。
• Keratin fibre dyeing composition comprising a particular aminosilicone
  申请人：——

  公开号：US20030140429A1

  公开（公告）日：2003-07-31

  The disclosure relates to a composition for dyeing human keratin fibres, such as hair, comprising in a cosmetically acceptable medium at least one direct dye or at least one oxidation dye and at least one aminosilicone. The disclosure further relates to dyeing devices and methods employing the composition.

  该披露涉及一种用于染色人类角蛋白纤维，例如头发的组合物，其中在化妆品可接受的介质中包含至少一种直接染料或至少一种氧化染料和至少一种氨基硅油。该披露还涉及使用该组合物的染色装置和方法。