4,5-二甲基补骨脂素 | 4046-74-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4,5-二甲基补骨脂素
• 中文别名: 苯丙醇,a-1-丙烯-1-基-
• 英文名称: 2,5-dimethylfuro<3,2-g>benzopyran-7-one
• 英文别名: 2,5-dimethylfuro<3,2-g>benzopyran-7(H)-one；4,5'-dimethylpsoralen；2,5-dimethyl-furo[3,2-g]chromen-7-one；4-5'-dimethylpsoralen；2,5-Dimethyl-7-oxo-7H-furo<3.2-g><1>benzopyran；4.5'-Dimethyl-psoralen；4,5-Dimethylpsoralen；2,5-dimethylfuro[3,2-g]chromen-7-one
• CAS: 4046-74-6
• 化学式: C₁₃H₁₀O₃
• 分子量: 214.221
• InChiKey: GJYYXSDOKGEWNX-UHFFFAOYSA-N

物化性质

• 熔点：
  165.0-165.5 °C
• 沸点：
  381.5±37.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  4,5-二甲基补骨脂素 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.92h， 生成 7-N-methylpiperazinomethyl-4-methylpsoralen
  参考文献：
  名称：

  SYNTHESIS OF AMINOMETHYL ANGELICINS AND PSORALENS AS POTENTIAL CHEMOTHERAPEUTIC AGENTS

  摘要：

  DOI：

  10.1515/hc.2004.10.2-3.145
• 作为产物：
  描述：

  4-methyl-6-allyl-7-acetoxycoumarin 在 氢氧化钾 、 溴 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 2.33h， 生成 4,5-二甲基补骨脂素
  参考文献：
  名称：

  Rodighiero; Guiotto; Pastorini, Farmaco, Edizione Scientifica, 1981, vol. 36, # 7, p. 648 - 662

  摘要：

  DOI：

文献信息

• Device and method for photoactivation
  申请人：Cerus Corporation

  公开号：US20030170141A1

  公开（公告）日：2003-09-11

  A device comprising a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.

  一个装置包括一个光源、一个样品支架和一个温度控制隔室。样品支架被定位以支持多个样品容器，以便被光源照射。温度控制隔室保持样品容器的温度在所需范围内。光源、样品支架和温度控制隔室都包含在不透明的外壳内。
• Apparatus for reducing the functioning lymphocyte population in blood
  申请人：LEUKOCYTE RESEARCH, INC.

  公开号：EP0030358A2

  公开（公告）日：1981-06-17

  A method and system are disclosed for externally treating human blood, with the objective of reducing the functioning lymphocyte population in the blood system of a human subject. According to the method, blood is withdrawn from the subject and passed through an ultraviolet radiation field in the presence of from about 1 nanogram to 100 micrograms per ml of blood, of a dissolved psoralen capable of forming photoadducts with DNA, to thereby effect covalent bonding between the psoralen and the nucleic acid of the lymphocytes, thereby altering the said nucleic acid and inhibiting the metabolic processes of the lymphocytes; and thereupon returning the irradiated blood to the subject. The withdrawn blood may be formed into an extracorporeal stream and flowed through a treatment station whereat the irradiation is effected, as for example by exposure to UV energy in the wave lenght range of from about 3200 to 4000 Angstroms; and such flow process may be conducted on a continuous basis. If desired, at least portions of the treated blood may then be separated, as for example by a continuous centrifuge, before returning the remaining diverted blood to the subject.

  本发明公开了一种从外部处理人体血液的方法和系统，目的是减少人体血液系统中的功能淋巴细胞数量。根据该方法，从受试者体内抽取血液，在每毫升血液中含有约 1 纳克至 100 微克能与 DNA 形成光加合物的溶解补骨脂素的情况下，使血液通过紫外线辐射场，从而实现补骨脂素与淋巴细胞核酸之间的共价键合，从而改变上述核酸并抑制淋巴细胞的代谢过程；然后将经过辐照的血液送回受试者体内。抽出的血液可以形成体外血流，流经一个处理站，在该处理站中进行辐照，例如暴露于波长范围约为 3200 至 4000 埃的紫外线能量中；这种流动过程可以连续进行。如果需要，至少可以将处理过的部分血液分离出来，例如通过连续离心机分离，然后再将剩余的分流血液送回受试者体内。
• Photochemical decontamination treatment of whole blood or blood components
  申请人：DIAMOND SCIENTIFIC CO.

  公开号：EP0124363A2

  公开（公告）日：1984-11-07

  Biological compositions are freed of functional polynucleotides by treatment of the biological composition with psoralen derivatives under irradiation conditions in which the proteins retain their original physiological activities and any polynucleotide present is rendered inactive.

  在辐照条件下，用补骨脂素衍生物处理生物组合物，使蛋白质保持其原有的生理活性，而存在的任何多核苷酸则失去活性，从而使生物组合物中的功能性多核苷酸消失。
• Canine distemper virus vaccine
  申请人：DIAMOND SCIENTIFIC CO.

  公开号：EP0506147A2

  公开（公告）日：1992-09-30

  A vaccine composition for animals susceptible to infection by canine distemper virus is disclosed. The vaccine comprises an immunologically effective amount of an inactivated canine distemper virus in combination with a non-toxic pharmaceutically acceptable immunologic adjuvant, inactivation of the canine distemper virus being effected by exposure of the virus to long wavelength ultraviolet light ultraviolet radiation or gamma radiation in the presence of a furocoumarin.

  本发明公开了一种用于易受犬瘟热病毒感染的动物的疫苗组合物。该疫苗由免疫有效量的灭活犬瘟热病毒与无毒的药学上可接受的免疫佐剂组合而成，灭活犬瘟热病毒的方法是在呋喃香豆素的存在下，将病毒暴露于长波长紫外线或伽马射线中。
• A device for nucleic acid sterilization
  申请人：ISAACS, Stephen T.

  公开号：EP0890363A2

  公开（公告）日：1999-01-13

  The invention relates to a device, comprising means for providing electromagnetic radiation (101-106; 201-206; 301-308); means for supporting a sample (109;315) in a fixed relationship with said radiation providing means during irradiation; a housing (100;200;300) for containing said radiation providing means; and means for maintaining the temperature of said sample within a desired temperature range during said irradiation comprising a chamber (107;207;309) positioned interior to said housing and in a fixed relationship to said radiation providing means.

  本发明涉及一种设备，包括用于提供电磁辐射的装置（101-106；201-206；301-308）；用于在辐照期间支撑与所述辐射提供装置保持固定关系的样品（109；315）的装置；用于容纳所述辐射提供装置的外壳（100；200；300）；以及用于在所述辐照期间将所述样品的温度保持在所需温度范围内的装置，该装置包括一个位于所述外壳内部并与所述辐射提供装置保持固定关系的腔室（107；207；309）。