6-nitro-γ-carboline | 79642-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-nitro-γ-carboline
• 英文别名: 8-nitro-γ-carboline；8-Nitro-5h-pyrido[4,3-b]indole
• CAS: 79642-22-1
• 化学式: C₁₁H₇N₃O₂
• 分子量: 213.195
• InChiKey: XLGBKEYBUVBWDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-nitro-γ-carboline 在 溶剂黄146 、 三氟乙酸 、 锌 作用下， 生成 5H-吡啶并[4,3-B]吲哚-8-胺
  参考文献：
  名称：

  Lee, Ching-Shing; Ohta, Toshiharu; Shudo, Koichi, Heterocycles, 1981, vol. 16, # 7, p. 1081 - 1084

  摘要：

  DOI：
• 作为产物：
  描述：

  5H-吡啶并[4,3-b]吲哚 在 硫酸 、 硝酸 作用下， 反应 4.0h， 以75%的产率得到6-nitro-γ-carboline
  参考文献：
  名称：

  Design, synthesis, and quantitative structure–activity relationship of cytotoxic γ-carboline derivatives

  摘要：

  Three series of gamma-carboline derivatives were designed and synthesized. All the compounds were tested for their cytotoxic activities in vitro against five human tumor cell lines (A549, SGC, HCT116, MCF-7, K562) and one multi-drug resistant subline (K562R). Most compounds showed moderate to potent cytotoxic activities against the tested cell lines. Sulfonate 11f exhibited more potent cytotoxic activities against almost all of the tested cells in comparison with the positive control, taxol, with IC50 values ranging from 0.15 to 4.5 mu M. The structure-activity relationships were discussed and a statistically reliable QSAR model (r(2) = 0.936, q(2) = 0.581) was established by the CoMFA analysis performed using the cytotoxic data against K562 cell line as a template. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.03.037

文献信息

• Design, synthesis, and quantitative structure–activity relationship of cytotoxic γ-carboline derivatives
  作者：Jing Chen、Xiaowu Dong、Tao Liu、Jianshu Lou、Chaoyi Jiang、Wenhai Huang、Qiaojun He、Bo Yang、Yongzhou Hu

  DOI：10.1016/j.bmc.2009.03.037

  日期：2009.5

  Three series of gamma-carboline derivatives were designed and synthesized. All the compounds were tested for their cytotoxic activities in vitro against five human tumor cell lines (A549, SGC, HCT116, MCF-7, K562) and one multi-drug resistant subline (K562R). Most compounds showed moderate to potent cytotoxic activities against the tested cell lines. Sulfonate 11f exhibited more potent cytotoxic activities against almost all of the tested cells in comparison with the positive control, taxol, with IC50 values ranging from 0.15 to 4.5 mu M. The structure-activity relationships were discussed and a statistically reliable QSAR model (r(2) = 0.936, q(2) = 0.581) was established by the CoMFA analysis performed using the cytotoxic data against K562 cell line as a template. (C) 2009 Elsevier Ltd. All rights reserved.
• Lee, Ching-Shing; Ohta, Toshiharu; Shudo, Koichi, Heterocycles, 1981, vol. 16, # 7, p. 1081 - 1084
  作者：Lee, Ching-Shing、Ohta, Toshiharu、Shudo, Koichi、Okamoto, Toshihiko

  DOI：——

  日期：——
• LEE CHING-SHING; OHTA TOSHIHARU; SHUDO KOICHI; OKAMOTO TOSHIHIKO, HETEROCYCLES, 1981, 16, NO 7, 1081-1084
  作者：LEE CHING-SHING、 OHTA TOSHIHARU、 SHUDO KOICHI、 OKAMOTO TOSHIHIKO

  DOI：——

  日期：——
• Design, synthesis, and biological evaluation of novel N-γ-carboline arylsulfonamides as anticancer agents
  作者：Jing Chen、Tao Liu、Rui Wu、Jianshu Lou、Ji Cao、Xiaowu Dong、Bo Yang、Qiaojun He、Yongzhou Hu

  DOI：10.1016/j.bmc.2010.10.047

  日期：2010.12

  A series of novel N-gamma-carboline arylsulfonamide derivatives designed based on the common feature of colchicine binding site inhibitors were synthesized and evaluated for their antiproliferative activity in vitro against five human cancer cell lines. Most of the compounds showed moderate to potent cytotoxic activities against all the tested cells. Preliminary mechanism research on one of the most potent compound 6p indicated that it was a potent tubulin polymerization inhibitor, with IC50 value of 3.8 mu M, equivalent to that of CA-4, and arresting cell cycle in G(2)/M phase. (C) 2010 Elsevier Ltd. All rights reserved.