3-(furan-2-yl)-1-(thiophen-3-yl)-propenone | 942055-32-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(furan-2-yl)-1-(thiophen-3-yl)-propenone
• 英文别名: 3-(Furan-2-yl)-1-thiophen-3-ylprop-2-en-1-one；3-(furan-2-yl)-1-thiophen-3-ylprop-2-en-1-one
• CAS: 942055-32-5
• 化学式: C₁₁H₈O₂S
• 分子量: 204.249
• InChiKey: NZTKBOYAHNEICL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[2-氧代-2-(噻吩-3-基)乙基]吡啶碘化物 、 3-(furan-2-yl)-1-(thiophen-3-yl)-propenone 在 ammonium acetate 作用下， 以 甲醇 为溶剂， 生成 4-(Furan-2-yl)-2,6-di(thiophen-3-yl)pyridine
  参考文献：
  名称：

  2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking study

  摘要：

  For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.041
• 作为产物：
  描述：

  糠醛 、 3-乙酰基噻吩 在 potassium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 以82.5%的产率得到3-(furan-2-yl)-1-(thiophen-3-yl)-propenone
  参考文献：
  名称：

  2-（噻吩-2-基或-3-基）-4-呋喃基-6-芳基吡啶衍生物的合成及其拓扑异构酶I和II的抑制活性，细胞毒性和结构-活性关系的评估

  摘要：

  设计，合成并合成了一系列2-（噻吩-2-基或-3-基）-4-呋喃基-6-芳基吡啶衍生物，并评估了它们对拓扑异构酶I和II的抑制作用以及对几种人类癌细胞系的细胞毒活性。化合物10 – 19具有中等的拓扑异构酶I和II抑制活性，化合物20 – 29具有显着的拓扑异构酶II抑制活性。结构-活性关系研究表明，4-（5-氯呋喃-2-基）-2-（噻吩-3-基）部分在显示拓扑异构酶II抑制中具有重要作用。

  DOI：

  10.1016/j.bmc.2010.01.065

文献信息

• Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship
  作者：Pritam Thapa、Radha Karki、Hoyoung Choi、Jae Hun Choi、Minho Yun、Byeong-Seon Jeong、Mi-Ja Jung、Jung Min Nam、Younghwa Na、Won-Jea Cho、Youngjoo Kwon、Eung-Seok Lee

  DOI：10.1016/j.bmc.2010.01.065

  日期：2010.3

  A series of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives were designed, synthesized, and evaluated for their topoisomerase I and II inhibition and cytotoxic activity against several human cancer cell lines. Compounds 10–19 showed moderate topoisomerase I and II inhibitory activity and 20–29 showed significant topoisomerase II inhibitory activity. Structure–activity relationship study

  设计，合成并合成了一系列2-（噻吩-2-基或-3-基）-4-呋喃基-6-芳基吡啶衍生物，并评估了它们对拓扑异构酶I和II的抑制作用以及对几种人类癌细胞系的细胞毒活性。化合物10 – 19具有中等的拓扑异构酶I和II抑制活性，化合物20 – 29具有显着的拓扑异构酶II抑制活性。结构-活性关系研究表明，4-（5-氯呋喃-2-基）-2-（噻吩-3-基）部分在显示拓扑异构酶II抑制中具有重要作用。
• 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking study
  作者：Arjun Basnet、Pritam Thapa、Radha Karki、Hoyoung Choi、Jae Hun Choi、Minho Yun、Byeong-Seon Jeong、Yurngdong Jahng、Younghwa Na、Won-Jea Cho、Youngjoo Kwon、Chong-Soon Lee、Eung-Seok Lee

  DOI：10.1016/j.bmcl.2009.11.041

  日期：2010.1

  For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. (C) 2009 Elsevier Ltd. All rights reserved.