1,5-anhydro-D-altritol | 27518-98-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,5-anhydro-D-altritol
• 英文别名: 1,5-Anhydro-D-altrit；1,5-Anhydro-D-mannitol；1,5-Anhydro-D-altit；(2R,3S,4S,5R)-2-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 27518-98-5
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: MPCAJMNYNOGXPB-ARQDHWQXSA-N

物化性质

• 熔点：
  127-129 °C
• 沸点：
  376.8±42.0 °C(Predicted)
• 密度：
  1.533±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,5-anhydro-D-altritol 生成 [(3R,4R,5S,6S)-4,5-diacetyloxy-6-(chloromethyl)oxan-3-yl] acetate
  参考文献：
  名称：

  WISNIEWSKI, ANDRZEJ;SKORUPOWA, EUGENIA;SOKOLOWSKI, JANUSZ;ROZANSKI, LECH;+, J. CARBOHYDR. CHEM., 8,(1989) N, C. 73-83

  摘要：

  DOI：
• 作为产物：
  描述：

  D-塔格糖 生成 1,5-anhydro-D-altritol
  参考文献：
  名称：

  GAREGG, PER J.;LINDBERG, BENGT;KONRADSSON, PETER;KVARNSTROM, INGEMAR, CARBOHYDR. RES., 176,(1988) N 1, 145-148

  摘要：

  DOI：

文献信息

• ANTIBACTERIAL AGENT
  申请人：JUNTENDO EDUCATIONAL FOUNDATION

  公开号：US20150322033A1

  公开（公告）日：2015-11-12

  An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R 1 and R 4 represents hydrogen atom, hydroxyl group, or a lower alkoxy group; R 2 and R 3 represents hydrogen atom or hydroxyl group; W represents hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R 1′ and R 5′ represents hydrogen atom; R 2′ and R 3′ represents hydrogen atom, hydroxyl group, or a lower alkoxy group; and R 4′ represents hydrogen atom or hydroxyl group).

  一种抗菌剂，包括以下一般式（I）所代表的化合物，该化合物可以对已经对喹诺酮产生抗药性的细菌表现出强效的抗菌活性（在该式中，R1和R4代表氢原子、羟基或较低的烷氧基；R2和R3代表氢原子或羟基；W代表氢原子、较低的环烷基或较低的烷氧基；R1'和R5'代表氢原子；R2'和R3'代表氢原子、羟基或较低的烷氧基；R4'代表氢原子或羟基）。
• 一种D-半乳糖键接的开环葫芦脲及应用
  申请人：昆明理工大学

  公开号：CN108003198B

  公开（公告）日：2021-06-18

  本发明属于超分子药物载体领域，公开了一种D‑半乳糖键接的开环葫芦脲；其结构式如下式所示：，其中R为或卤素，且R至少有一个为；本发明含D‑半乳糖基团的开环葫芦脲是具有内腔的大环穴状配体，开环使大环的环刚性减小，有极强的主‑客体键合能力；本发明含半乳糖的开环葫芦脲具有良好的水溶性，可以作为药物载体被广泛应用于药物的运输途径，同时可以大大提高生物利用度和药物的稳定性，且含半乳糖的开环葫芦脲具有潜在的肿瘤细胞靶向性。
• Alkylated hexitol nucleoside analogues and oligomers thereof
  申请人：——

  公开号：US20040033967A1

  公开（公告）日：2004-02-19

  The present invention is directed to nucleoside analogues with as substitute for the sugar part a 1,5-anhydrohexitol moiety, doexygenated and substituted with a nucleobase at the 2-position, of which the hexitorl ring is further substituted with at least one alkoxy substituent at the 3-position or at the 1-position, and to oligonucleotides wherein at least some of the nucleotides are part of the afore mentioned hexitol nucleoside analogues and exhibit sequence-specific hydridization to complementary sequences of nucleic acids, and maintaining or improving the hybridisation strength. The invention further relates to nucleoside analogues with a 1,5-anhydrohexitol moiety as the sugar part, deoxygenated and substituted with a nucleobase at the 2-position, of which the hexitol ring is substituted with a methoxy substituent at the 1-position, having at the same time either a hydroxy or an alkoxy group at the 3-position, or having a 3-deoxygenated position. The inclusion of one or more of the afore mentioned hexitol nucleoside analogues in oligonucleotides provides, inter alia, either for improved binding or for maintained binding of these oligonucleotides to a complementary strand. This invention further relates to the chemical synthesis of these oligomers which are useful diagnostics, therapeutics and as research agents.

  本发明涉及以1,5-脱水己糖基取代糖部分的核苷类似物，其在2位上以核碱基进行脱氧和取代，其中己糖环在3位或1位进一步取代至少一个烷氧基取代基，以及寡核苷酸，其中至少一些核苷酸是前述己糖核苷类似物的一部分，并对核酸的互补序列表现出序列特异性杂交，并维持或提高杂交强度。本发明还涉及以1,5-脱水己糖基为糖部分、在2位上脱氧和取代核碱基、在己糖环上以甲氧基取代基在1位取代、同时在3位具有羟基或烷氧基，或者在3位脱氧的核苷类似物。在寡核苷酸中包含前述己糖核苷类似物中的一个或多个，可提供改进的结合或维持这些寡核苷酸与互补链的结合。本发明还涉及这些寡聚体的化学合成，它们是有用的诊断、治疗和研究试剂。
• Compositions for improving the health and appearance of skin
  申请人：Algenist Holdings, Inc.

  公开号：US10231907B2

  公开（公告）日：2019-03-19

  Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.

  本文提供了微藻护肤组合物以及改善皮肤健康和外观的方法。还提供了将多糖用于局部个人护理产品、化妆品和除皱组合物等应用的方法。本发明还提供了用于改善皮肤健康和外观的新型脱色微藻组合物。本发明还包括用于人体皮肤的不溶性多糖颗粒。
• [EN] CODRUG THAT DISINTEGRATES IN INTESTINE, PREPARATION THEREFOR, AND USE THEREOF<br/>[FR] CO-MÉDICAMENT SE DÉSINTÉGRANT DANS L'INTESTIN, SA PRÉPARATION ET SON UTILISATION<br/>[ZH] 一类肠道裂解型共药及其制备和用途
  申请人：ENNOVABIO ZHEJIANG PHARMACEUTICALS CO LTD

  公开号：WO2022012693A1

  公开（公告）日：2022-01-20

  本发明涉及一类肠道裂解型共药（Codrug）及其制备和用途，具体地，本发明提供了一种如式I所示的共药化合物。本发明还提供了使用这类化合物治疗胃肠道自身免疫性疾病、炎症性疾病和癌症的方法；以及用于制备这类化合物的方法和中间物。