1-[4-(p-methylphenyl)-2-thiazolyl]-3-(2-thienyl)-5-(p-methylphenyl)-2-pyrazoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[4-(p-methylphenyl)-2-thiazolyl]-3-(2-thienyl)-5-(p-methylphenyl)-2-pyrazoline
• 英文别名: 4-(p-Tolyl)-2-[3-(p-tolyl)-5-(2-thienyl)-3,4-dihydropyrazol-2-yl]thiazole；4-(4-methylphenyl)-2-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-1,3-thiazole
• 化学式: C₂₄H₂₁N₃S₂
• 分子量: 415.583
• InChiKey: AELMIOASZLIZIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  85
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-(4-methylphenyl)-1-(thiophen-2-yl)prop-2-en-1-one 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 9.0h， 生成 1-[4-(p-methylphenyl)-2-thiazolyl]-3-(2-thienyl)-5-(p-methylphenyl)-2-pyrazoline
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of Some Thiazolyl-Pyrazoline Derivatives

  摘要：

  Some 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives (TP 1-28) were synthesized by reacting substituted 3-(2-thienyl)-5-aryl-1-thiocarbamoyl-2-pyrazolines (P 1-7) with phenacyl bromides in ethanol. Structures of the synthesized compounds were confirmed by elemental analyses and IR, H-1-NMR and MS-FAB(+) spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3704), Staphylococcus aureus (NRLL B-767), Salmonella typhimurium (NRRL B-4420), Bacillus cereus (NRRL B-3711), Listeria monocytogenes (Ankara University, Faculty of Veterinary, Ankara, Turkey), Aeromonas hydrophila (Ankara University, Faculty of Veterinary Ankara, Turkey), Candida albicans, and Candida glabrata (isolates obtained from Osmangazi University, Faculty of Medicine, Eskisehir Turkey) were investigated. A significant level of activity was illustrated.

  DOI：

  10.1080/10426500601047529