1-Butanone, 4-((2-hydroxyethyl)methylamino)-1-(2-thienyl)- | 141809-41-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Butanone, 4-((2-hydroxyethyl)methylamino)-1-(2-thienyl)-
• 英文别名: 4-[2-hydroxyethyl(methyl)amino]-1-thiophen-2-ylbutan-1-one
• CAS: 141809-41-8
• 化学式: C₁₁H₁₇NO₂S
• mdl: MFCD01656322
• 分子量: 227.327
• InChiKey: PZOZYCKECVFWJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.545
• 拓扑面积：
  68.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Butanone, 4-((2-hydroxyethyl)methylamino)-1-(2-thienyl)- 、 盐酸 以31%的产率得到
  参考文献：
  名称：

  HADJIPAVLOU-LITINA, D.;REKKA, E.;HADJIPETROU-KOUROUNAKIS, L.;KOUROUNAKIS,+, EUR. J. MED. CHEM., 26,(1991) N, C. 85-90

  摘要：

  DOI：
• 作为产物：
  描述：

  N-甲基-2-羟基乙胺 、 4-氯-1-(2-噻吩基)丁酮 以 乙醇 为溶剂， 以31%的产率得到1-Butanone, 4-((2-hydroxyethyl)methylamino)-1-(2-thienyl)-
  参考文献：
  名称：

  Synthesis and biological studies of some novel antiinflammatory aryl-hydroxy-amino-ketones

  摘要：

  The synthesis of some 4-hydroxy-(or amino)-ethyl-amino butyrophenones or butyrothienones is described. The interconversion of these compounds to the corresponding 5-aryl-4-oxa-1-azabicyclo[3,3,0]octanes is presented. The title compounds demonstrated good antiinflammatory activity in the adjuvant induced disease model. They also possessed antinociceptive, immuno-modulating and antioxidant activity, properties which are probably involved in the mechanism of their action.

  DOI：

  10.1016/0223-5234(91)90216-a

文献信息

• HADJIPAVLOU-LITINA, D.;REKKA, E.;HADJIPETROU-KOUROUNAKIS, L.;KOUROUNAKIS,+, EUR. J. MED. CHEM., 26,(1991) N, C. 85-90
  作者：HADJIPAVLOU-LITINA, D.、REKKA, E.、HADJIPETROU-KOUROUNAKIS, L.、KOUROUNAKIS,+

  DOI：——

  日期：——
• Synthesis and biological studies of some novel antiinflammatory aryl-hydroxy-amino-ketones
  作者：D Hadjipavlou-Litina、E Rekka、L Hadjipetrou-Kourounakis、P Kourounakis

  DOI：10.1016/0223-5234(91)90216-a

  日期：1991.1

  The synthesis of some 4-hydroxy-(or amino)-ethyl-amino butyrophenones or butyrothienones is described. The interconversion of these compounds to the corresponding 5-aryl-4-oxa-1-azabicyclo[3,3,0]octanes is presented. The title compounds demonstrated good antiinflammatory activity in the adjuvant induced disease model. They also possessed antinociceptive, immuno-modulating and antioxidant activity, properties which are probably involved in the mechanism of their action.