(E)-methyl 7-methyl-3,9-dioxo-11-(3-oxo-3-p-tolylprop-1-enyl)-3,9-dihydrochromeno[8,7-h]chromene-2-carboxylate | 1323444-53-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-methyl 7-methyl-3,9-dioxo-11-(3-oxo-3-p-tolylprop-1-enyl)-3,9-dihydrochromeno[8,7-h]chromene-2-carboxylate
• 英文别名: methyl 7-methyl-11-[(E)-3-(4-methylphenyl)-3-oxoprop-1-enyl]-3,9-dioxochromeno[8,7-h]chromene-2-carboxylate
• CAS: 1323444-53-6
• 化学式: C₂₉H₂₀O₇
• 分子量: 480.474
• InChiKey: ZBKGAPCLULAKCN-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1,5-二羟基萘 在 哌啶 、 盐酸 、 对甲苯磺酸 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 乙醇 、 水 为溶剂， 反应 18.5h， 生成 (E)-methyl 7-methyl-3,9-dioxo-11-(3-oxo-3-p-tolylprop-1-enyl)-3,9-dihydrochromeno[8,7-h]chromene-2-carboxylate
  参考文献：
  名称：

  Synthesis and anti-inflammatory activity of novel biscoumarin–chalcone hybrids

  摘要：

  A series of synthesized novel biscoumarin-chalcone hybrids were evaluated for their anti-inflammatory and antioxidant activity. The tested compounds significantly inhibit the carrageenin induced paw oedema in albino rats and also exhibit important scavenging activities. These compounds thus constitute an interesting template for the design of new therapeutic tools against inflammation. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.002

文献信息

• Synthesis and anti-inflammatory activity of novel biscoumarin–chalcone hybrids
  作者：Koneni V. Sashidhara、Manoj Kumar、Ram K. Modukuri、Ravi Sonkar、Gitika Bhatia、A.K. Khanna、Shivika Rai、Rakesh Shukla

  DOI：10.1016/j.bmcl.2011.06.002

  日期：2011.8

  A series of synthesized novel biscoumarin-chalcone hybrids were evaluated for their anti-inflammatory and antioxidant activity. The tested compounds significantly inhibit the carrageenin induced paw oedema in albino rats and also exhibit important scavenging activities. These compounds thus constitute an interesting template for the design of new therapeutic tools against inflammation. (C) 2011 Elsevier Ltd. All rights reserved.